Prediction of Malaria Outcome and Its Complication Throught Estimation of Biochemical Marker of Serum Lactate
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 2
Abstract
Introduction: Malaria is a widespread disease in the tropics, including India Plasmodium vivax is the most prevalent species and Plasmodium falciparum is the most virulent one worldwide. Lactate dehydrogenase (LDH) is an intracellular enzyme which can be elevated in malaria and can be used to know the outcome of severe malariaand its prognosis.Materials And Method: Optimal test detecting the plasmodium lactate dehydrogenase (rapid diagnosis) was also used in all patients of confirmed cases of malaria, The kit used for estimation of plasma lactate levels was the Randox Kit manufactured by (Randox Laboratories Ltd, 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4, QY). Lactate levels were estimated using biochemistry analyzer TRACE 30 v4.1. Hyperlactatemia was defined as serum lactate levels more than 2 mmol/l.Results: Out of the 50 patients of malaria, 50% had P.vivax, 35% had P.falciparum, and 15% had mixed infection. Males were 67% of the patients and 33% of patients were females. Increase in level of serum lactate correlated with increase in bloodpressure of patients, decrease in platelets count, bilirubin level, serumcreatinine.Conclusion: Serum lactate levels can be independently used as an indicator of severity of complications and mortality.
Authors and Affiliations
Dr Laxmi Agrawal
Keywords
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