Prediction of Prostate Cancer by Analyzing of Serum Trace Elements
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 12
Abstract
Abstract: Worldwide 1.1 million men were diagnosed with prostate cancer in 2012. In India, it is the second most widespread cancer in Indian males. Despite the far-reaching experimental and clinical studies over decades, the pathogenesis of Prostate cancer remains unidentified. The biochemical and molecular mechanisms accountable for and associated specifically with the development and progression of Prostate cancer are largely unidentified. The amalgamation of molecular/biochemical relationships is required to identify critical events in Prostate cancer process. Prostate cancer is a vital and potentially fatal disease in humans. Both genetic and environmental risk factors are associated with increased risk of prostate cancer among Asian populations. Previous observations have shown that trace elements play various roles in human health. The trace elements such as copper, iron and zinc are known to be associated with prostate cancer, but their functions are unclear. Theaim of present study to evaluate the variation of serum trace mineral (iron, copper and zinc) and other special parameters (ferritin and ceruloplasmin) level with healthy men and those with prostate cancer. A total of 100 histopathologically proven prostate cancer patients was participated in this study from the MGM medical college associated with MY Hospital;their age range was (50–75) years and 100 healthy men matched in age as a control group during the period from year2014 to year 2015 after the diagnosis using a histopathological examination of the malignant tumour, the blood was centrifuged and serum samples resultant were unconnected and stored until the assay time. The analysis of the data showed that the mean values of serum copper were significantly increased (P < 0.001) and Serum Zinc were significantly decreased (P < 0.001) and serum iron is non-significant in prostate cancer patients as compared to normal healthy control. Other special parameters serum ferritin and ceruloplasmin were significantly increased in prostate cancer cases (P < 0.01) as compared to normal healthy male control. Serum PSA was significantly increasing (P < 0.001) in prostate cancer patients as compared to normal healthy controls and mean value progressively increase with the grades of cancer. In conclusion, serum ferritin, ceruloplasmin, zinc and copper is significantly associated with prostate cancer and may serve as a non-invasive biomarker to complement the PSA test in the diagnosis and prognostic assessment of prostate cancer. Keywords:Prostate cancer, traces elements, copper, zinc, ferritin, ceruloplasmin.
Authors and Affiliations
PoornimaDey Sarkar, Amrita Vamne
Keywords
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