Prediction of Significant Neonatal Hyperbilirubinemia on The Basis of Cord Serum Albumin Level in Healthy Term Neonates.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Objective: To study the association of cord serum albumin (CSA) level with incidence of neonatal hyperbilirubinemia (NNH) in term neonates. Method: We conducted a prospective study on 100 sequentially born term babies. Cord blood collected at birth was analyzed for estimation of serum albumin. After a follow up of 3 days, venous sample was taken at 72 hrs of age and analyzed for total serum bilirubin (TSB) level. A value of TSB ≥17 mg/dl at 72 hours of life was taken as significant NNH. Neonates were divided into 3 groups according to their cord serum albumin (CSA) levels; group A with CSA <2.8 gm/dl, group B with CSA 2.8-3.3 gm/dl and group C with CSA >3.3 gm/dl and incidence of significant hyperbilirubinemia was studied in all these groups. Results: There were 13 neonates in groups A , 57 in group B and 30 in group C. Out of 13 neonates in group A, 5 (38.5%) developed significant NNH; in group B, 7 (12.3%) out of 57 neonates developed NNH whereas in group C, 2 (6.7%) neonates out of 30 developed NNH. This difference in the incidence of significant NNH amongst the three groups was statistically significant (p=0.02). We also calculated and compared mean day 3 TSB levels of the three groups. The mean day 3 TSB level was highest in group A (14.6±3.62 mg %), 12.1±3.25 mg% in group B and lowest (11.0±3.28 mg %) in group C. On comparing these means by ANOVA, statistically significant difference was found (p=0.005). Conclusion: High CSA level is associated with a lower incidence of significant NNH. Hence, this can be used as a potential tool for prediction of hyperbilirubinemia in neonates.
Authors and Affiliations
Dr. Surendra Kumar, Dr. Karnika Agrawal, Dr. Anupam Chaturvedi
Keywords
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- EP ID EP370316
- DOI 10.9790/0853-1704015762.
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