Predictive and Prognostic Molecular Factors in High Grade Gliomas
Journal Title: Scholars Journal of Medical Case Reports - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Gliomas are the most common primary brain tumor in adults. In addition to the histological grade, knowledge at the molecular level of these tumors is important in the management of these tumors. 1p/19q-codeletion is an important molecular factor seen in oligodendroglial grade tumors and also confers a favorable prognosis as well as predicts good response to chemotherapy and radiotherapy. IDH mutation also helps in better prognosticating patients with grade III gliomas. Patients of glioblastoma with methylated MGMT promoter, confers a survival advantage when treated with temozolomide and thus acts as a predictive marker. These various molecular factors help's not only in prognosticating glioma patients but also aids in tailoring treatment.
Authors and Affiliations
Minu Reeba Thomas
Keywords
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