Predictive Value of Hormonal Evaluation Before Prostate Needle Biopsy on Prostate Cancer T Stage and Prognosis
Journal Title: Üroonkoloji Bülteni - Year 2018, Vol 17, Issue 1
Abstract
Objective: In this study we evaluated the hormone data before prostate needle biopsy (PNB) in patients who underwent retropubic radical prostatectomy (RRP) due to prostate adenocarcinoma (PCa). Correlations between the patients’ RRP pathology results, recurrence-free survival (RFS), and hormone data were investigated. Materials and Methods: Patients were evaluated in two groups according to RRP pathologic T stage: T2 (group 1) and T3 (group 2). Then patients were assessed in two groups based on total testosterone (TTE) values: >300 ng/dL and <300 ng/dL. The preoperative data, hormone data, RRP pathologic data, and biochemical recurrence and RFS results were compared between these groups. Results: A total of 81 patients were evaluated. The mean follow-up time was 37.7 months. Mean recurrence free survival (RFS) among all patients was 94.2±7 months. In multivariate analysis of the preoperative data, TTE/prostate volume (p=0.015) and PNB tumor percentage (p=0.004) were significantly higher in group 2 (n=32) compared to group 1 (n=49). In the postoperative data, RRP pathology Gleason score (GS) (p=0.015) and tumor volume (p=0.02) were significantly higher in group 2. RFS was 99.2±5.8 months in group 1 and 77±12.1 months in group 2 (p=0.02). When patients were assessed according to TTE levels, of the pre- and postoperative data only RRP pathology T stage, GS, and lymph node positivity were significantly higher in the TTE <300 ng/dL group (n=30) compared to the TTE >300 ng/dL group (n=51). The biochemical recurrence rates and RFS times (87.7±13.8 months and 91.3±6.4 months, respectively) were similar between the groups (p=0.571). Conclusion: We demonstrated a correlation between locally invasive PCa and low TTE measured before PNB and low TTE density. In particular, TTE values <300 ng/dL were associated with high pathologic T stage, GS, and lymph node positivity.
Authors and Affiliations
Serdar Çelik, Ozan Bozkurt, Hüseyin Alperen Yıldız, Ömer Demir, Burçin Tuna, Kutsal Yörükoğlu, Güven Aslan
Keywords
Related Articles
- EP ID EP379683
- DOI 10.4274/uob.942
- Views 96
- Downloads 0
Partial Urethrectomy for Female Urethral Transitional Epithelial Cell Carcinoma
To present a female case of partial urethrectomy and the following adjuvant chemo-radio-therapy for urethral transitional epithelial cell carcinoma originating from distal urethra in the light of literature. The patient...
Additional Surgical Procedures During Postchemotherapy Retroperitoneal Lymph Node Dissection in Patients with Nonseminomatous Testicular Tumor
Objective: Retroperitoneal lymph node dissection (RLND) is frequently performed in non-seminomatous testicular tumor (TT) patients, especially in cases who have radiological residual mass despite normal tumor markers aft...
Controversies in Radical Cystectomy: Meta-Analysis and Systemic Comparison of Open Surgery with Laparoscopic and Robotic Surgery
Open radical cystectomy (ORC) is the standard treatment modality in high-risk non-muscle-invasive and invasive bladder carcinoma. Although it has some advantages, oncologic outcomes of ORC are associated with high morbid...
Transurethral Resection of the Bladder Tumor Success Rates of Surgeons and Possible Causes of Differences Between Locals and Refugees
Objective: In our study, we examined the success rates of our surgeons and the criteria that define the success, and tried to reveal the possible causes of the differences in the success rates of transurethral resection...
What is the Color of Cancer?
Objective: To investigate the colors that evokes cancer in the patients with prostate, lung and breast cancer, and in healthy controls. Materials and Methods: A visual card in one of the 9 colors (white, red, orange, ye...