Predictive Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Measured Prior to Prostate Biopsy
Journal Title: Journal of Urological Surgery - Year 2020, Vol 7, Issue 1
Abstract
Objective: We planned to investigate the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting prostate cancer (PCa). Materials and Methods: We enrolled 302 male patients who underwent prostate biopsy between January 2013 and June 2018. We recorded anthropometric indices, demographic parameters, physical examination, laboratory values, in addition to results of radiologic imaging and pathological examination. The patients were divided into two groups as patients with benign prostatic hyperplasia (BPH) and those with PCa. We investigated the association of NLR and PLR with histopathology. Results: The mean age of the patients was 66.2±8.2 years. Patients with prostate adenocarcinoma were older, had higher prostate-specific antigen (PSA) concentrations, neutrophil count, and had lower hemoglobin, platelet count and prostate volume (PV) compared to patients with BPH. Receiver operating characteristic analysis identified that NLR values above 2.43 indicated 1.68 fold (95% CI: 1.06-2.66; p=0.028) higher risk for prostate adenocarcinoma. NLR correlated positively with age, and PSA, negatively with hemoglobin and platelet count. NLR and PV were the independent predictors of biopsy histopathology. Conclusion: We demonstrated that NLR is independently associated with PCa in patients undergoing prostatic biopsy due to high PSA levels.
Authors and Affiliations
Hüseyin Eren
Keywords
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- EP ID EP685307
- DOI 10.4274/jus.galenos.2020.3210
- Views 190
- Downloads 0
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