Predictive Value of Urinary Neutrophil Gelatinase-associated Lipocalin and Serum Ischemia-modified Albumin for Early Diagnosis in Patients with Contrast-induced Acute Kidney Injury
Journal Title: The Medical Bulletin of Haseki - Year 2020, Vol 58, Issue 3
Abstract
Aim: The aim of this study was to investigate whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum ischemia-modified albumin (IMA) levels could serve as early biomarkers of contrast-induced acute kidney injury (CI-AKI) in patients with normal serum creatinine values who undergo coronary angiography (CAG). Methods: This study was conducted in 78 patients undergoing CAG. Urinary NGAL and serum IMA values which measured prior to and 6 hours after CAG were compared with creatinine values that measured prior to and 48 hours after CAG. Results: IMA and NGAL values obtained 6 hours after CAG differed significantly from those obtained at baseline. Statistically significant differences were found between the baseline and 6th-hour values of urinary NGAL and serum IMA (p<0.001). There was no significant difference between baseline and 48th hour serum creatinine levels (p=0.081). In addition, a statistically significant positive correlation was found between pre-processing and 6th-hour NGAL and IMA levels, (r=0.277, p=0.014; r=0.407 and p<0.001, respectively). Conclusion: An increase in urinary NGAL and serum IMA levels were detected without an increase in serum creatinine values which is routinely used in determining CI-AKI. When compared to serum creatinine, urinary NGAL and serum IMA may be early and sensitive biomarkers for predicting CI-AKI.
Authors and Affiliations
Ziya Apaydın, Alparslan Kılıç, Berkay Ekici, Aycan Fahri Erkan, Sedat Özdemir, Ali Kemal Oğuz
Keywords
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- EP ID EP685285
- DOI 10.4274/haseki.galenos.2020.5847
- Views 164
- Downloads 0
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