Predictors of dengue severity
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 5
Abstract
Pone et al., in a study published in this Journal, have attempted to identify historical or observable signs or symptoms that reliably predict worsening of dengue disease in children.1 In so doing, they have coined a new term “serious dengue disease” and adopted a new clinical outcome metric, “treatment modality.” The “treatment modalities” chosen include administration of “amines, inotropes, colloids, mechanical ventilation, non-invasive ventilation, peritoneal dialysis or hemodialysis.” Lethargy, abdominal distension, pleural effusion, and hypoalbuminemia were the most reliable markers of serious dengue disease identified in 145 children hospitalized in Rio de Janeiro in 2007–2008, who had direct or indirect evidence of recent dengue infection. The authors are among those who would agree that a more accurate identification of dengue predictors would best be derived from large protocol-based prospective studies of physiologically characterized laboratory confirmed dengue illnesses.
Authors and Affiliations
Scott Halstead
Keywords
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- EP ID EP512005
- DOI 10.1016/j.jped.2016.06.004
- Views 66
- Downloads 0
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Author's reply: Maternal hypertension and infant growth
We appreciate the comments and questions about our study, which demonstrates the careful and correct assessment that focused on one aspect of concern in cohort studies: the possibility of selection bias.1