Predictors of mortality among adult patients enrolled on Antiretroviral Therapy in Hiwotfana specialized University Hospital, Eastern Ethiopia: Retrospective Cohort study
Journal Title: Journal of HIV for Clinical and Scientific Research - Year 2018, Vol 5, Issue 1
Abstract
Objective: Mortality of HumanImmunodeficiency Virus (HIV)- infected patients have been reduced substantially since the introduction of Antiretroviral Therapy (ART). However, many studies have shown high mortality. But the factors associated with this high mortality are poorly characterized. So this retrospective cohort study aims to determine mortality and identify predictors of it among patients on ART at Hiwotfana specialized university Hospital (HFSUH). Result: A total of 61 (11.9%) deaths were observed giving an overall mortality rate of 2.8 per 100 person years. Advanced WHO stages (hazard ratio (HR) =3.44, 95% CI: 1.73 - 6.85), baseline CD4 count less than 200cells/mm3 (HR=3.18, 955 CI: 1.671- 6.06), regimen changed (HR=23.62, 95% CI: 9.95 - 56.05), and being anemic (HR=3.23, 95% CI: 1.71 - 6.11) were the independent predictors of mortality. Patients who started AZT based initial regimen had a lower risk of mortality (HR=0.29, 95% CI=0.13 - 0.64) when compared with the D4T based regimen.
Authors and Affiliations
EM Eticha, AB Gemeda
Keywords
Related Articles
- EP ID EP533943
- DOI 10.17352/2455-3786.000127
- Views 76
- Downloads 0
The Impact of a Holistic Intervention on Self-Efficacy and Risk of Depression in HIV-Infected Individuals in Denmark
Introduction: Human immunodeficiency virus (HIV) infection is a stressful disease, and depression is frequently experienced by HIV-infected individuals. The aim of this pilot study was to investigate whether a holistic i...
Pseudomembranous Candidiasis Indicates High Level Drug Resistance among Patients on Antiretroviral Treatment in Nairobi East District, Kenya
Objectives: The aim of this study was to determine antiretroviral drug resistance patterns in patients on long-term antiretroviral therapy presenting with OPC. Methods: An exploratory survey was performed among HIV-infec...
Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel for...
Socio-demographic and immunological profile of HIV patients attending ART clinic in a tertiary care hospital in North India
Background: The epidemiology of HIV should be understood especially with regard to various socio-demographic factors because the most effective approaches for its prevention and control are awareness and life style chang...
Commentary: Role of MicroRNAs in HIV Related Studies
Micro RNAs (miRNAs) are well known regulatory factor of physiological and developmental processes, it has been revealed that many miRNAs contribute the initiation and progression of various cancers. Micro RNAs are being...