PREDICTORS OF RISK FOR CORONARY ARTERY LESIONS IN WOMEN WITH SYMPTOMS OF CORONARY ARTERY DISEASE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 52
Abstract
BACKGROUND Coronary artery disease is a leading cause of mortality and morbidity in the world. Women differ from men with regard to coronary artery disease in presentation, risk factors, prognosis and in acceptance of secondary prevention modalities. With regard to presentation, most of the women with coronary artery disease present at a later age. MATERIALS AND METHODS Female patients with STEMI, NSTEMI or chronic stable angina without significant comorbidities were studied and results were analysed. RESULTS 140 subjects were included in the study. The mean age of patients was 54.19±9.89 years, maximum number of patients were >60 yrs. of age. 21 (15%) were premenopausal and rest 119 (85%) were postmenopausal. 95 (68%) patients had angiographic evidence of CAD while coronary angiography was normal in 45 (32%) patients. Total cholesterol, LDL, HDL were found to be significant from bivariable analysis, but in multivariable analysis, single independent predictor of a lesion in the coronary arteries was found to be HDL cholesterol with adjusted risk ratio of 1.3 (1.1-1.5). CONCLUSION Women with acute coronary syndromes present more with unstable angina/NSTEMI. Women are less likely to present with the syndrome associated with occlusive thrombus- that is, with infarction with ST elevation. Family history of premature coronary artery disease is an important risk factor in women. Total cholesterol, LDL, HDL were found to be significant from bivariable analysis, but in multivariable analysis, single independent predictor of a lesion in the coronary arteries was found to be HDL cholesterol.
Authors and Affiliations
Manoj Ravi, Nisha Narendran, Zinia Thajudeen Nujum
Keywords
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- EP ID EP608446
- DOI 10.18410/jebmh/2018/724
- Views 77
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