Preemptive effect of low dose of ketamine for cholecystectomy

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Preemptive effect of low dose of ketamine for cholecystectomy

Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2006, Vol 8, Issue 2

Abstract

Background and aim: Preemptive analgesia is one of the pain sedative methods which is based on the blocking of pain receptor before any painful stimulation. Ketamine is a NMDA (N-Methyl D-Aspartate) receptor blocker, which has been used to reduce central sensitization. This study was performed to evaluate the preemptive effect of low dose ketamine (0.5 mg/kg, i.v.) on postoperative pain of cholecystectomy. Methods: In this study, sixty patients aged 30-60 years, with Anesthesia Society of America Scoring I or II (ASA I or II), candidate for elective cholecystectomy were randomly divided into two groups. The same operation and general anesthetic methods were used for the two groups. The patients in group1 received 0.5 mg/kg ketamine, 20 min. before surgical incision and normal saline (the same volume), 20 min. after the operation. The patients of group 2, received normal saline (0.5 mg/kg) 20 min. before surgical incision and ketamine (0.5 mg/kg) 20 min. after that. In the postoperative period, analgesia was maintained with pethidine Using Visual Analogue Scale (VAS), pain was measured at 0 (arousal), 6, 12 and 24 hrs after the operation. The time interval for the first request of analgesia and the total amount of analgesic consumption during 24 hrs were reported. The data was analyzed using t and 2 tests. Results: The mean value of pain intensity at 0, 6, 12 and 24 hrs after the operation in group 1 (3.240.97) was significantly less that that of the group 2 (4.181.09) (p

Authors and Affiliations

hafez Gaher, hosain Taheri, aliakbar Bighi , reyhanak Talakob

Keywords

EP ID EP118380
DOI -
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