Preemptive Use of Ketamine in Postoperative Pain in Breast Cancer Surgery
Journal Title: GCSMC Journal of Medical Sciences - Year 2016, Vol 5, Issue 2
Abstract
Background: There is a widespread belief among clinician that Ketamine is effective as a preemptive analgesic. Modified radical mastectomy (MRM) is one of the most common cancer surgeries in females and commonly followed by acute postoperative pain. In our study we evaluated whether the preemptive use of ketamine controls postoperative pain in female patients undergoing breast cancer surgery. Materials & Methods: 60 adult female patients undergoing modified radical mastectomy were randomized into two groups of 30 patients each. Ketamine (K) group received 0.5 mg/kg Ketamine intravenously with induction of anesthesia. In the control(C) group 0.5 mg/kg normal saline was injected. All patients received general anesthesia. Postoperatively, complain of pain at rest and on shoulder movement using visual analogue score (VAS), time of request for first analgesic, total number of analgesic injection & postoperative any complications of drugs were recorded in post anesthetic care unit for 24 hours. Result: For all of the evaluated times, the VAS score was significantly lower in the Ketamine group when compared to control group. The interval time for the first Diclofenac inj. was 33.1±4.7 minute for the Ketamine group and 20.3±5.2 for the control group (P=0.0001).Postoperatively, in the first 24 hours, the total number of Diclofenac inj. was 0.6±0.6 for the Ketamine group and 1.0±0.8 for the control group. (P=0.05) No patients had ketamine related side effects. Conclusion: A subanaesthetic dose of intravenously administered Ketamine had a preemptive analgesic effect in control of pain after modified radical mastectomy.
Authors and Affiliations
Rekha Solanki, Bhavna Shah, Bipin Patel, Nilesh Goswami, Milan Vaza
Keywords
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