PREFORMULATION STUDIES OF SIMVASTATIN FOR TRANSDERMAL DRUG DELIVERY SYSTEM 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9

Abstract

The aim of the present work to study the preformulation parameters for Transdermal drug delivery system. The objective of Preformulation study is to generic information useful to the formulater in developing stable and bioavailable dosage form. The use of Preformulation parameter maximizes the chances in formulation an acceptable, safe, efficacious and stable product and at the same time provide the basis for optimization of the drug product quality. Administration of conventional tablets of simvastatin has been reported to exhibit fluctuations in plasma drug levels, resulting either in manifestation of side effects or reduction in drug concentration at the receptor sites also, the maintenance of a constant plasma concentration of a cardiovascular drug is important in ensuring the desired therapeutic response, again since the half life of simvastatin is 3 hours hence multiple doses of the drug are needed to maintain a constant plasma concentration for a good therapeutic response, and improve patient compliance, hence the objective of the study was made to develop controlled release TDDS of simvastatin using polymer like HPMC and Carbopol, which will controlled the release of drug, increasing the bioavailability of the drug and thus decreasing the dosing frequency of the drug. The Preformulation studies were carried out in terms of testa for identification (physical appearance, melting point, and uv spectrophotometer), solubility profile, determination of partition coefficient and quantitative estimation of drug. All the observation and results showed that the simvastatin could serve as suitable candidate for Transdermal drug delivery system that may improve the bioavailability. 

Authors and Affiliations

Sameer Singh , Narendra Mandoria, Anis shaikh

Keywords

Related Articles

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF METOPROLOL SUCCINATE AND ATORVASTATIN CALCIUM IN A PHARMACEUTICAL DOSAGE FORM 

A new, simple, precise, accurate and selective high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of Metoprolol succinate and Atorvastatin calci...

OVERVIEWS OF THE TREATMENT AND CONTROL OF COMMON FISH DISEASES 

Similar to other animals, fish can also suffer from different diseases. All fish carry pathogens and parasites. Disease is a prime agent affecting fish mortality, especially when fish are young. Pathogens which can cause...

A SIMPLE RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE AND EMTRICITABINE IN TABLET DOSAGE FORM  

A rapid, specific, sensitive and simple high performance liquid chromatography was developed for simultaneous estimation of Tenofovir Disoproxil Fumarate and Emtricitabine in tablet formulation. The separation was achie...

SYNTHESIS, CHARACTERIZATION OF SOME NOVEL PYRAZOLES AND THEIR GROWTH PROMOTING ACTIVITY ON SOME FLOWERING PLANTS  

A series of chlorosubstituted 4-aroylpyrazoles have been synthesized by refluxing of chlorosubstituted-3-aroylflavones and 3-alkoylchromone with phenylhydrazine hydrochloride in dioxane medium with 0.5 ml of piperidine....

FACILE SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF FGVR 

A rational designing of linear Tetrapeptide FGVR was done and was synthesized by solution phase peptide synthesis. The docking studies of designed linear tetrapeptide FGVR was carried out by using Schrodinger Software So...

Download PDF file
  • EP ID EP114417
  • DOI -
  • Views 86
  • Downloads 0

How To Cite

Sameer Singh, Narendra Mandoria, Anis shaikh (2012). PREFORMULATION STUDIES OF SIMVASTATIN FOR TRANSDERMAL DRUG DELIVERY SYSTEM . International Research Journal of Pharmacy (IRJP), 3(9), 159-161. https://europub.co.uk/articles/-A-114417