Pregabalin versus Gabapentin in the Management of Painful Diabetic Neuropathy
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 10
Abstract
Diabetic neuropathy develops in the majority of poorly controlled diabetic patients as a late complication. Painful diabetic neuropathy represents a major health problem as it may present with excruciating neuropathic pain and is responsible for substantial morbidity, increased mortality and impaired quality of life. The aim is to compare the efficacy of Pregabalin and Gabapentin in painful diabetic neuropathy. This study was conducted on 100 diagnosed patients of diabetes with painful diabetic neuropathy presenting in the department of Medicine of a tertiary care teaching hospital of Punjab, India. Patients were divided in two groups of 50 each. Pregabalin (150-300 mg/day) was administered to group I and Gabapentin (300-2400 mg/day) to group II for 6 weeks. Follow up assessment of various clinical parameters was done at weekly intervals while Visual Analogue Scale (VAS) Score and Likert Scale Score assessments were done at 2, 4 and 6 weeks of treatment. Overall, it was observed that both Pregabalin and Gabapentin showed an improvement in VAS score and Likert scale score, but the improvement was significantly more with Pregabalin than Gabapentin. In this study, Pregabalin was clearly superior to Gabapentin in the improvement of parameters like spontaneous pain, burning sensation and numbness. This study concluded that it is important to treat patients with painful diabetic neuropathy with tailor-made approach. Monotherapy with Pregabalin or Gabapentin produced clinically meaningful pain relief however; pain reduction was superior with Pregabalin compared to Gabapentin. Therefore, it is suggested that Pregabalin could be a better therapeutic option in patients with painful diabetic neuropathy. Keywords: diabetes, painful, neuropathy, Pregabalin, Gabapentin
Authors and Affiliations
Dr. Tejvir Singh, Dr. Sumit Pal Singh Chawla, Dr. Monika Gulia, Dr. Sarabjot Kaur
Keywords
Related Articles
- EP ID EP372357
- DOI -
- Views 102
- Downloads 0
Analysis of Stability parameters in the bivoltine breeds of silkworm Bombyx mori L
Abstract: Genotype-environment (G-E) interaction and stability parameters were analyzed for ten each of oval and dumbbell silkworm bivoltine genotypes reared during three different seasons of the year. Quantitative econo...
A case of para meniscal cyst of knee managed arthroscopically
Lateral Meniscal cysts are more common than the medial meniscus cysts, almost 10 times more common [1]. Trauma is the main etiology for meniscal cysts. 20 years old female came with complaints of pain and swelling the in...
Moniliosis of Seminiferous Fruit in the Gardens of Uzbekistan
The article analyses the increase of moniliosis disease in seminiferous fruit trees in the gardens of the Republic of Uzbekistan, caused damage, spread of disease in the plains, foothills and mountainous areas, plantatio...
An eco-friendly approach to reduce reproductive attributes in the housefly, Musca domestica L. using crude plant extracts
Abstract: As an alternative to chemical insecticides, plant extracts showing insecticidal properties are being increasingly used nowadays in insect pest management programs. With a view to an eco-friendly approach, here...
Nutrient Consumption and Hygiene and Sanitation Practices of Primary School Children (Urban & Rural) in Bareilly, Uttar Pradesh
Children form an important proportion of the vital human potential of any country and therefore their health and wellbeing is of great importance. Like preschool children, primary school children are of concern from nut...