Pregnancy and Childbirth in Patients With Syndrome-MarfanPregnancy and Childbirth in Patients With Syndrome-Marfan
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2017, Vol 4, Issue 1
Abstract
Marfan syndrome (MFS) is an autosomal dominant condition with a reported incidence rate of 1 in 3000 to 5000 individuals. The majority of cases of MFS are caused by a mutation in the fibrillin-1 gene (FBN1). Transforming growth factor β (TGF-β) plays an important role in Marfan syndrome. The identification of the FBN-1 mutation will help identify potentially affected family members and promote prenatal diagnostic testing. β blockers decrease myocardial contractility and pulse pressure and may also improve the elastic properties of the aorta. Angiotensin II-receptor blockers attenuate the clinical manifestations of MFS.
Authors and Affiliations
Fasoulakis N. Zacharias
Keywords
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- EP ID EP553814
- DOI 10.17140/ GOROJ-4-137
- Views 167
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