PREGNANCY OUTCOME IN MATERNAL CRIGLER-NAJJAR SYNDROME 1 AND 2 : A CASE REPORT AND SYSTEMATIC REVIEW OF LITERATURE
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 12
Abstract
Background: Crigler-najjar syndrome is a rare inherited disorder of congenital unconjugated hyperbilirubinemia and few cases of CNS with pregnancy have been reported till date. Objective: To report a case of maternal Crigler-Najjar syndrome in pregnancy, To review all the cases of CNS 1 and 2 reported in literature till date and evaluate maternal and fetal outcome in these cases. Materials and Methods: PubMed and Google Scholar database was searched for case reports of CNS in pregnancy using key words: Crigler- Najjar syndrome and/in pregnancy ,phototherapy, phenobarbital and pregnancy, till 12th November 2017. Results: A total of 21 pregnancies were reported in 15 patients of CNS (excluding our patient). Maternal- fetal outcome was favorable in most cases with appropriate treatment with phototherapy and low dose phenobarbital. Conclusion: CNS is a rare cause of jaundice in pregnancy. Serum bilirubin levels should be kept below 10mg/dl by judicious treatment for optimal outcome.
Authors and Affiliations
Dr. Aishwarya Kapur, Dr Ankit Jain, Dr Sangeeta Gupta, Dr. Sudha Prasad
Keywords
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