Preimplantation Genetic Diagnosis for Human Leukocyte Antigen Matching: The Generation of the Savior Sibling and the “Gift of Life”
Journal Title: Women's Health Science Journal - Year 2018, Vol 2, Issue 2
Abstract
In vitro fertilization (IVF) in conjunction with preimplantation genetic diagnosis (PGD) for mutation detection and human leukocyte antigen (HLA) matching for hematopoietic stem cell transplantation (HSCT) is a unique technology of modern clinical embryology. The technology should be offered to any family with a condition that requires matched-related HSCT. Today, PGD-HLA matching is a realistic option for families in need of treating an affected sibling, when no HLA-matched donor is available. Offering the option of HSCT from a savior sibling immediately upon the diagnosis of the condition in the child of a family is crucial, since it shortens the time until the birth of the savior sibling through IVF-PGD and increases the probability of cure by HSCT. The success of the treatment can be achieved only through a multidisciplinary team work and the cure can be “gifted” to the sick child through the savior sibling.
Authors and Affiliations
Economou KA*
The Impact of Sex Education among Brazilian Adolescents
By entering into the reality of public schools in Juiz de Fora (MG), the present study aims to describe the scenario of adolescent’s sexual experience altogether with its risks and consequences, considering previous rese...
Acute Intestinal Ischemia and Mesenteric Vein Thrombosis with Mortality During Pregnancy
Objective: We present a case of acute intestinal ischemia and mesenteric venosus thrombosis in a first trimester pregnant woman with surgical treatment. Case presentation and intervention: Our case was a 23-year-old mult...
Racial Disparities and the Effect of Maternal Sexually Transmitted Infections on Adverse Birth Outcomes
Background: Understanding the role of sexually transmitted infections (STIs) in disparities associated with adverse birth outcomes (ABOs) may help target specific interventions for black and white women. Despite extensiv...
Two Products to Prevent and Maintain Healthy Vagina
A common problem that women face is to maintain healthy vagina. It is an extra-ordinary organ. While the normal pH of the body is 7.4, the pH of a healthy vagina is around 4.5. The acidic pH of the vagina in contrast to...
Important Female Factors Affecting Success in Assisted Reproductive Technology Procedures
Infertility is a hot topic in the field of public health, affecting about 48.5 million couples worldwide with significant psychological, social, medical and economic consequences. Assisted Reproductive Technology offers...