Preimplantation Genetic Diagnosis for Human Leukocyte Antigen Matching: The Generation of the Savior Sibling and the “Gift of Life”
Journal Title: Women's Health Science Journal - Year 2018, Vol 2, Issue 2
Abstract
In vitro fertilization (IVF) in conjunction with preimplantation genetic diagnosis (PGD) for mutation detection and human leukocyte antigen (HLA) matching for hematopoietic stem cell transplantation (HSCT) is a unique technology of modern clinical embryology. The technology should be offered to any family with a condition that requires matched-related HSCT. Today, PGD-HLA matching is a realistic option for families in need of treating an affected sibling, when no HLA-matched donor is available. Offering the option of HSCT from a savior sibling immediately upon the diagnosis of the condition in the child of a family is crucial, since it shortens the time until the birth of the savior sibling through IVF-PGD and increases the probability of cure by HSCT. The success of the treatment can be achieved only through a multidisciplinary team work and the cure can be “gifted” to the sick child through the savior sibling.
Authors and Affiliations
Economou KA*
Keywords
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- EP ID EP745808
- DOI 10.23880/whsj-16000115
- Views 61
- Downloads 0
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