PRELIMINARY ACUTE ORAL TOXICITY STUDY OF THE WATER EXTRACT OF PHYSALIS MINIMA LEAVES
Journal Title: Journal of Biological and Scientific Opinion - Year 2018, Vol 6, Issue 5
Abstract
Physalis minima has been used in traditional medicine for the treatment of different ailments. Thus, it is necessary to evaluate the toxicity of this plant’s extract to prevent any unwanted side effects. This study aimed to determine the acute oral toxicity level of water extract of P. minima leaves on female Sprague Dawley rats at a dosage of 2000 mg/kg for a period of 14 days using the Organisation for Economic Co-Operation and Development (OECD) Guideline 423. The findings showed no mortality and no change in behavioural pattern. Besides, the body weight of rats increased throughout the study. The rats’ internal organs showed a normal histopathological architecture compared to the control group. Hence, it can be concluded that the oral administration of water extract of P. minima did not produce any significant toxic effects on rats.
Authors and Affiliations
Noor Zafirah Ismail, Hasni Arsad, Nur Afiqah Lokman, Nurul Izzati Jaafar, Nor Hasyimah Haron
Keywords
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- EP ID EP651172
- DOI 10.7897/2321-6328.06595
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