PRELIMINARY ACUTE ORAL TOXICITY STUDY OF THE WATER EXTRACT OF PHYSALIS MINIMA LEAVES
Journal Title: Journal of Biological and Scientific Opinion - Year 2018, Vol 6, Issue 5
Abstract
Physalis minima has been used in traditional medicine for the treatment of different ailments. Thus, it is necessary to evaluate the toxicity of this plant’s extract to prevent any unwanted side effects. This study aimed to determine the acute oral toxicity level of water extract of P. minima leaves on female Sprague Dawley rats at a dosage of 2000 mg/kg for a period of 14 days using the Organisation for Economic Co-Operation and Development (OECD) Guideline 423. The findings showed no mortality and no change in behavioural pattern. Besides, the body weight of rats increased throughout the study. The rats’ internal organs showed a normal histopathological architecture compared to the control group. Hence, it can be concluded that the oral administration of water extract of P. minima did not produce any significant toxic effects on rats.
Authors and Affiliations
Noor Zafirah Ismail, Hasni Arsad, Nur Afiqah Lokman, Nurul Izzati Jaafar, Nor Hasyimah Haron
Keywords
Related Articles
- EP ID EP651172
- DOI 10.7897/2321-6328.06595
- Views 115
- Downloads 0
AN AYURVEDA APPROACH IN THE MANAGEMENT OF VERNAL KERATO CONJUNCTIVITIS: A CASE STUDY
Vernal kerato conjunctivitis(VKC) or spring catarrh is a recurrent, bilateral and self-limiting inflammation of conjunctiva, having a periodic seasonal incidence. It is an allergic disorder in Which IgE mediated mechanis...
A REVIEW ON CLINICAL APPLICATION OF THE CONCEPT OF BALAGRAHA IN MODERN TIMES
Kaumarbhritya is a branch of Astanga Ayurveda that defines a unique concept regarding disease caused by unidentified vectors known as Balagraha. Unfortunately it is abandoned in today’s era due to its mythological explan...
AWARENESS OF PEOPLE TO ATTEND FREE MEDICAL CAMP CONDUCTED IN SOUTH INDIAN TERTIARY CARE HOSPITAL
Prevention and treatment of medical issues are the main task of a health service at a youth camp. However, only few reports about organization and implementation of camp health care are available. This makes it difficult...
MOLECULAR DOCKING AND BIOAVAILABILITY STUDIES OF CAFFEINE AND CAFFEIC ACID COMPOUNDS WITH APOPTOSIS REGULATED PROTEINS
Oral squamous cell carcinoma is the most common type of oral cancer accounting for almost 90 % of all oral malignancies, around 20 % of cancer burden in India. Caffeine and caffeic acid widely present in many fruits, veg...
GENETIC VARIABILITY AND SELECTION CRITERIA IN RICE
Genetic parameters, correlation and path analysis for 12 yield and quality traits were studied during rabi, 2009-10 in 21 genotypes of rice. High estimates of GCV were recorded for plant height, number of filled grains/p...