Preliminary analysis of qualitative changes in suspended red blood cells under different low-pressure and hypoxic conditions
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 1
Abstract
Objective To evaluate the quality of suspended red blood cells (SRBC) under low-pressure and hypoxic conditions, in order to lay a theoretical foundation for airline delivery, air drop and storage of SRBC on plateau. Methods The low-pressure and hypoxic conditions (0.026 MPa and 0.047 MPa) were simulated by a pressure control device. SRBC were divided into 3 groups (5 bags/group, 1.5 U/bag). Each group was stored in 0.026 MPa environment at 2℃-6℃ for 24 hours (named 0.026 MPa), in 0.047MPa environment at 2℃-6℃ for 7 days (named 0.047 MPa), and in a blood storage refrigerator at 4℃ (named the control), respectively. The storage cell characteristics were examined on day 2, 9, 14, 28 and 35. Results We found that HCT, MCV, K+, Na+, FHb, hemolytic ratio, 2, 3-DPG and rheological properties in group 0.026 MPa and 0.047 MPa were not significant different compared with that in control (P>0.05). The consumptions of Glu in group 0.026 MPa and 0.047 MPa were significantly higher (P<0.05), and a transient increase in LAC concentration of group 0.026 MPa and 0.047MPa were observed, compared to the control. Conclusion The conditions of low-pressure and hypoxia have no significant effect on the quality of suspended red blood cells.
Authors and Affiliations
Xuelian YONG, Li ZOU, Lei LIU, Qian ZANG, Jinxiu JI, Si CHENG, Yongqiang LI
Keywords
Related Articles
- EP ID EP738455
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.01.004
- Views 5
- Downloads 0
Current situation of blood donation of ethnic minorities in Pu′er City, 2019~2021.
Objective To investigate the participation of ethnic minorities in voluntary blood donation, so as to provide research basis for understanding and promoting blood donation of local ethnic minorities, and further improve...
Enhancing the sensitivity of HIV DNA detection: a magnetic bead-based method
Objective To establish a magnetic bead enrichment strategy for the detection of human immunodeficiency virus deoxyribonucleic acid (HIV DNA) in peripheral blood, and to verify the improvement of the sensitivity of this m...
Analysis of blood component transfusion and some adverse reactions in myelodysplastic syndroms patients
Objective To analyze the blood transfusion and adverse reactions in myelodysplastic syndroms (MDS) patients, so as to improve transfusion management in MDS patients. Methods The diagnosis and treatment information of MDS...
Molecular genetic analysis and predigree of a new FUT1 allele of para-Bombay blood group: a case report
Objective To study the serological and molecular mechanism of a case of para-Bombay blood group caused by 236delG mutation of FUT1 gene and investigate the pedigree. Methods The ABO, H and Lewis antigens of the proband a...
Adverse reactions to blood transfusion: A retrospective analysis of 814 cases in Qingdao area from 2020 to 2021
Objective To investigate the incidence and composition of adverse reactions to blood transfusion(ARBT) in Qingdao hospitals in recent years. Methods The "Statistical Table of Adverse Reactions to Blood Transfusion in Med...