Preliminary Investigation of the Subchronic Hypolipidemic Actions of Hibiscus sabdariffa in Rats
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 7, Issue 2
Abstract
Hibiscus sabdariffa is a popular medicinal plant that is claimed to have hypotensive and hypocholesterolemic actions in animals. The present preliminary study was conducted to assess the subchronic hypolipidemic actions of H. sabdariffa calyx in normal rats when administered as an aqueous extract. Twenty (20) Wistar albino rats were used for this study and were assigned into 4 groups. Group 1 rats were normal control and received distilled water (10 ml/kg) while Groups 2-4 rats received 200, 400 and 600 mg/kg body weight of the extract respectively. All treatments were through the oral route for 21 days. On the 21st day, blood samples for Lipid panel analyses were collected. The results disclosed statistically significant (p < 0.05), dose-dependent decreases in Low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triacylglycerol (TAG) levels in all doses of the extract-treated groups (Groups 2-4) when compared to that of the normal control rats. No statistically significant change (p > 0.05) was observed in the total cholesterol level of groups 2, 3 & 4 given 200, 400 and 600 mg/kg of the extract, respectively compared to the normal control (Group 1). However, there was a significant increase (p < 0.05) in high density lipoprotein (HDL) levels of the extract-treated group when compared to that of the normal control rats. It was concluded that aqueous extract of H. sabdariffa, administered subchronically, exhibited beneficial hypolipidemic effects in healthy rats and warrants further laboratory and clinical investigations to define its potential benefits and risk for the treatment of lipid disorders.
Authors and Affiliations
Patrick Emeka Aba, Amarachi Ossai, Ernest Chukwuamachago Nweze
Keywords
Related Articles
- EP ID EP328423
- DOI 10.9734/JAMPS/2016/23186
- Views 92
- Downloads 0
Anxiolytic Effect of Aqueous Root Extract of Citrus aurantium in Wistar Albino Rats
Anxiety is a very common mental disorder among neurological disorders. Citrus aurantium decoction has been used to treat anxiety- like behaviour, by traditional medicine practitioners in Nasarawa State, Nigeria. The aim...
Biochemical Effects of Telfairia occidentalis Leaf Extracts against Copper-induced Oxidative Stress and Histopathological Abnormalities
This study was carried out to investigate the protective effect of oral administration of T. occidentalis against copper induced oxidative stress. Forty two adult male Wistar rats were divided equally into six groups. Gr...
Antiretroviral Therapy Contribution to Patients Health in New Juaben Municipality
Our study focused on identifying factors underlining the deteriorating health condition of people living with HIV/AIDS (PLWHA) in the New Juaben Municipality. After a review of the relevant literature, the following hypo...
Assessment of Thrombolytic Activity of Selected Species from Lamiaceae Family Growing Naturally in Kurdistan Region\Iraq Using In-vitro Model
Aims: The present study was aimed to assess most commonly used medicinal plant belong to Lamiaceae family for their thrombolytic activity. Place and Duration of the Study: Pharmacy College\ Hawler Medical University, Ju...
Assessment of Risk Involved in the Combination Medicine of Paracetamol and Caffeine
Paracetamol (acetaminophen) with caffeine is a combination medicine indicated for the temporary relief of pain and discomfort associated with a number of conditions such as headache or muscle pain. There is a controversy...