PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ANTINOCICEPTIVE ACTIVITY STUDIES WITH METHANOL EXTRACT OF WHOLE PLANTS OF SENNA OBTUSIFOLIA
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Objective: The objective of the present study was to phytochemically screen and evaluate the antinociceptive potential of methanolic extract of Senna obtusifolia whole plants. Methods: Extract was administered orally at doses of 50-400 mg/kg. Antinociceptive activity was assessed in intraperitoneally injected acetic acid-induced pain model. Results: In acetic acid-induced pain model, the extract reduced the number of abdominal constrictions by 20.0, 40.0, 51.4, and 62.9%, respectively, at doses of 50, 100, 200 and 400 mg/kg. A standard analgesic drug, aspirin (200 and 400 mg/kg) reduced abdominal constrictions by 40.0 and 65.7%, respectively. Conclusion: The extract possesses significant antinociceptive potential.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
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