PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL PROPERTIES OF CRUDE LEAVES EXTRACT AND FRACTIONS OF ACACIA NILOTICA (LINN.)
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 3
Abstract
Infectious diseases caused by bacteria, fungi, parasites and viruses are still a major threat to public health. Their impact is particularly large in developing countries due to the relative unavailability of medicines and the emergence of widespread drug resistance. This has lead to the search of new antimicrobial agents mainly among plant extracts. As part of our ongoing research to purify, isolate and characterized antibacterial compounds from the extracts of some Nigerian medicinal plants, Acacia nilotica (Linn.) was screened for its preliminary phytochemical and antibacterial activity. The preliminary phytochemical screening of the extracts was carried out using standard methods while the antibacterial activity was done using disc diffusion method. The results for the phytochemical screening showed the presence of most of the phytochemicals tested. The results for the antibacterial activity of the crude methanolic extract and fractions of the leaf of Acacia nilotica showed varying degree of antibacterial activity against the bacterial isolates. However, crude methanolic extract, ethyl acetate and butanol fractions showed relatively high zone of inhibition (mm), minimum inhibitory concentrarion (MIC) and minimum bactericidal concentration (MBC). They were found to inhibit the growth of most of the test bacterial isolates comprising of both Grampositive and Gram-negative organisms. On the other hand, hexane and aqueous fractions shows little or no activity against tested isolate. These findings support previous reports on the antimicrobial activity of this plants. The result of the present study signifies the potential of Acacia nilotica leaf as a source of therapeutic agents, which may provide leads in the ongoing search for antimicrobial agents from plants.
Authors and Affiliations
A. Abdulhamid
Keywords
Related Articles
- EP ID EP620079
- DOI -
- Views 114
- Downloads 0
ESTIMATION OF LOSARTAN POTASSIUM IN PHARMACEUTICAL FORMULATIONS: APPLICATION TO CONTENT UNIFORMITY TESTING
A simple, accurate, precise, rapid, economical and sensitive Uv spectrophotometric method has been developed for the estimation of losartan potassium in pharmaceutical preparations and environmental wastewater samples, w...
SAFETY AND IMMUNOGENICITY OF SEASONAL TRIVALENT INACTIVATED INFLUENZA VACCINES IN PREGNANT WOMEN
Pregnant women are at high risk for influenza virus infection and serious influenza-related complications and are recommended to receive inactivated influenza vaccine during the influenza season. Before 2009, although ma...
BREASTFEEDING AND STANYAJANAN GANA IN CHARAK SAMHITA
Future physical and mental growth and development of baby solely depend upon successful breastfeeding right from first day of birth. Since ancient time awareness of importance of breastfeeding is there. Breastfeeding pro...
PHARMACEUTICO - ANALYTICAL STUDY OF SOMA YOGA
Soma yoga is an important formulation in shwas rogadhikar in the Sidha yoga sangraha of Yadav ji Trikam Ji. At the time of present study not much research work was done on this formulation. Somlata is known for its anti-...
A COMPARATIVE STUDY BETWEEN TRAMADOL AND FENTANYL IN SPINAL ANESTHESIA IN CESAREAN SECTION
Study Objective: Studying the efficacy of adding tramadol to spinal anesthesics for postoperative analgesia. Setting: This study was carried out in the department of anesthesia and reanimation at Alkark Hospital, during...