Preliminary Study of Hypoglycaemic and Hypolipidemic Activity of Aqueous Root Extract of Ricinus Communis in Alloxan-Induced Diabetic Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 10
Abstract
Since diabetes mellitus is a major risk factor that leads to secondary conditions like cardiovascular disease, management of the condition include controlling other risk factors that may lead to secondary conditions in addition to managing diabetes, the primary condition.This work aimed at investigating the hypoglycaemic potential, lipid profile effects and phytochemistry of Ricinus communis L (root). Powdered root of Ricinus communis was subjected to phytochemical analysis. A dose of 500mg/kg crude aqueous root extract was administered orally to alloxan-induced diabetic rats. Diabetic rats administered Glibenclamide orally served as the positive controls. Fasting blood glucose was monitored daily. Serum lipid profile was analyzed on the last day of the experiment. Coronary Risk Index (CRI) was calculated from the lipid profile parameters. The extract reduced fasting blood glucose by 61.9% and glibenclamide by 69.8%. The root extract caused a significant reduction in CRI of the rats under study. Tannin, saponin, cardenolide and alkaloid were detected in the plant. The detected bioactive principles were probably responsible for the hypoglycaemic effect observed. The reduced CRI observed also showed the potential of the extract in reducing artherosclerosis, a complication of diabetes.
Authors and Affiliations
O. O. Matthew , L. Olusola , A. O. Matthew
Keywords
Related Articles
- EP ID EP151697
- DOI -
- Views 77
- Downloads 0
Neuropathy in Insulin Resistant & Insulin Sensitive People
The objective of the study was to evaluate whether cardiac autonomic neuropathy was associated with insulin resistance in centrally obese people of Bhavnagar. Materials and methods: This cross sectional, case control stu...
The Combined Effect of Injectable Recombinant Erythropoietin and Oral Iron on the Hematopoiesis of Extremely Overweight Neonates
Erythropoietin is the major regulating blood flow hormone which can be effect on hematopoiesis of premature infants. The aim of this study was to examine the effectiveness of intravenous recombinant erythropoietin regime...
Effects of Water Crude Leaf Extract of Moringa Oleifera Lam (Moringaceae) on Normotensive Rat Blood Pressure and Isolated Duodenum
Moringa oleifera is used in folk medicine for the treatment of many ailments among which, hypertension and intestinal disorders. The aim of this study was to investigate the hypotensive and/or antihypertensive activity o...
Review of the survey of Entamoeba Histolytica in Children; a Brief Focus on Nigeria Situation: a Review
Amoebiasis has been a big problem of human civilization at the beginning of 21st century, so every study from this field is valuable. E. histolytica infection is endemic in most temperate and tropical climates in develop...
Monitoring Milk Urea Level and Feed Ration as a Potential Tool for Milk Quality
Milk quality appreciation parameters are not determined in Tunisia yet. Indeed, the variety of herds used, breeding systems and climatic conditions show a big variety of milk composition. The present study aims to quanti...