PRELIMINARY SURVEY OF COUNTERFEITING OF ALBENDAZOLE AND METRONIDAZOLE MARKETED IN LUBUMBASHI
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Objective: Counterfeit medicines represent a major health risk in the treatment of various pathologies. They are responsible for resistance emergence in the treatment of infectious diseases. This study was conducted in order to identify illegal and legal drugs marketed in the city of Lubumbashi and assess the quality of all samples concerned by this study.Methods: The study included albendazole and metronidazole for oral administration. Visual inspection of medicines, investigation of the authenticity of drugs from pharmaceutical regulatory authorities, and determination of content were used as study parameters.Results: A total of 34 samples were collected including 19 of albendazole and 15 of metronidazole. 11 (32%) samples were not permitted to be marketed. 9 (26 %) samples were substandard according to the US Pharmacopoeia in terms of the content of active ingredient: all of them, the active ingredient was found to present in a lower amount (under-dosing). The proportion of non-compliance is highest among medicines not permitted to be marketed (78% vs 8.0%; p˂0.005). Conclusion: It is obvious that strengthening the capacity of drug regulatory authority of the DR Congo can reduce the influx of counterfeit/substandard drugs in Lubumbashi.Keywords: Medicines, Counterfeiting, Antiparasitics, DR Congo, Lubumbashi
Authors and Affiliations
Pierrot Mwamba T, Pierre Duez, Jean Baptiste Kalonji N
Keywords
Related Articles
- EP ID EP576256
- DOI -
- Views 40
- Downloads 0
A COMPARATIVE EVALUATION OF ENZYMATIC ANTIOXIDANT LEVELS IN PRE AND POST THERAPY PATIENTS WITH ORAL CANCER
Objectives: The present study was aimed to evaluate the magnitude of oxidative stress and levels of enzymatic antioxidants in Oral Squamous cell carcinoma (OSCC) patients receiving radiotherapy (RT) and chemo radiotherap...
AN OVERVIEW ON THE BIOLOGICAL PERSPECTIVES OF SIDA CORDIFOLIA LINN
Plants have been used since ancient times to heal and cure diseases and to improve health and well being. Sida cordifolia Linn belonging to family Malvaceae is widely distributed throughout the plains of India. The vario...
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF FORMULATION CONTAINING CAMPHOR, MENTHOL AND THYMOL
Objective: To determine analgesic and anti-inflammatory activity of a oily formulation containing camphor, menthol and thymol as ingredients in wistar albino mice and rats.Methods: Acute toxicity studies were done as per...
DESIGN AND IN VITRO CHARACTERIZATION OF MUCOADHESIVE BUCCAL PATCHES OF DULOXETINE HYDROCHLORIDE
Objective: Buccal mucosa is a potential site for the delivery of drugs to the systemic circulation, a drug administered through the buccal mucosa enters directly to the systemic circulation, thereby which bypass the drug...
IN SILICO MODELLING OF β-LACTAM RESISTANT ENTEROCOCCUS FAECALIS PBP4 AND ITS INTERACTIONS WITH VARIOUS PHYTO-LIGANDS
Objective: The resistance to β-lactam antibiotics is a serious problem worldwide. This resistance has emerged due to two main mechanisms: production of β-lactamases that hydrolyses β-lactam antibiotics and other is th...