Premalignancies and intraepithelial neoplasms of the skin – an update

Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 3

Abstract

The process of skin carcinogenesis involves a series of transitional events, which can be initiated and promoted by many events such as exposure to physical or chemical carcinogens, chronic inflammation and viral infection.Precancerous skin lesions and carcinomas in situ of the skin represent the early stages of epithelial skin tumors. Clinical observations, histological analysis, as well as molecular and cytogenetic studies have shown actinic keratoses and Bowen’s disease to be precursors of squamous cell carcinomas. The presence of arsenical keratoses, tar-induced dermatosis and X-ray irradiation-related keratosis may be associated with basal and/or squamous cell skin cancers. Other intraepithelial neoplasms include mammary and extramammary Paget’s disease. Anogenital HPV can cause intraepithelial vulvar, penile and anal intraepithelial neoplasias, each named for the affected site: AIN (anal intraepithelial neoplasia), PIN (penile intraepithelial neoplasia), and VIN (vulvar intraepithelial neoplasia).This article provides an update on the diagnosis and management on these premalignant conditions.

Authors and Affiliations

Anna Lis-Święty

Keywords

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  • EP ID EP55013
  • DOI -
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How To Cite

Anna Lis-Święty (2015). Premalignancies and intraepithelial neoplasms of the skin – an update. Postępy Nauk Medycznych, 28(3), 193-199. https://europub.co.uk/articles/-A-55013