Premorbid Cognitive Dysfunction and Endophenotypes in Bipolar Disorder: A Rapid Review

Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 5

Abstract

On the contrary that happened with schizophrenia, it has not been completely clarify if cognitive alterations precede the illness or are a consequence of it. Although some data indicate that some cognitive deficits are already present before the illness begins, more studies are still needed.The poor existing evidence about these aspect indicated that premorbid bipolars patients did not show significate cognitive execution differences versus controls but they did versus premorbid schizophrenics [1] (even thought, these subjects were evaluated by a cognitive battery designed more for military purposes than clinical). Other studies have shown similar data, noting that, in contrast to other pathologies, severe premorbid cognitive dysfunction is not a dominant feature in bipolar disorder [2]. In general, these data would indicate that, if there is a premorbid cognitive malfunction, this would be mild or moderate. Other studies show that the severity of cognitive deficits in high-risk youth for bipolar disorder was relatively less pronounced compared to high-risk youth for schizophrenia, except for psychomotor speed, sustained attention and some executive aspects such as those based on the interference Stroop tests. Unlike schizophrenia, deficits in planning and working memory are not considered as factors of cognitive vulnerability.

Authors and Affiliations

J D Molina, E García Laredo

Keywords

Related Articles

How Does Stathmin Destabilize Microtubules?A Root of Consciousness and Alzheimer’s Disease

Alzheimer’s disease due to dementia and the memory brain that might be related to the microtubules disorder interrupt daily life. Alzheimer’s is a brain disease that causes a slow decline in concentrations, memory, think...

Platelet Function during Platelet-Rich Plasma Sequestration in Complex Cardiac Surgical Procedures - Prospective Controlled Study

Cardiopulmonary bypass (CPB) is associated with common activation of all four integral components of hemostasis, that is, the endothelium, plasma proteins, platelets and fibrinolysis. The causative factors include the pr...

The Effect of Granulocyte Colony Stimulating Factors (GCSF) on Expansion of CD34+ Hematopoietic Stem Cells

Stem cells are alternatives therapeutic treatment, mainly for diseases that cannot be treated by medical or surgical treatment. CD34+ hematopoietic stem cells which is isolated from autologous peripheral blood cell is a...

The Effectiveness of Life Skills Training on the Social Skills of Deaf Students

The aim of this research was to investigate the effectiveness of life skills training on the social skills of deaf students. The present research was used the experimental method with pretest, posttest design and a contr...

Erysipelas in Tunisian Patients: Epidemiological, Clinical Features and Risk Factors in Internal Medicine

Background: The purpose of our work was to study the epidemiological, clinical features and risk factors of erysipelas in Internal Medicine. Methods: Retrospective study including 86 patients with erysipelas collected at...

Download PDF file
  • EP ID EP587570
  • DOI 10.26717/BJSTR.2019.15.002794
  • Views 140
  • Downloads 0

How To Cite

J D Molina, E García Laredo (2019). Premorbid Cognitive Dysfunction and Endophenotypes in Bipolar Disorder: A Rapid Review. Biomedical Journal of Scientific & Technical Research (BJSTR), 15(5), 11712-11714. https://europub.co.uk/articles/-A-587570