Preoperative Biochemical, Haematological and Radiological Parameters in Breast Cancer: A Case-control Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
ABSTRACT Introduction: Haematological, biochemical and radiological investigations are prerequisite for surgical resection in breast cancer. Deranged parameters predict a poorer outcome following surgery and also may adversely influence the risk factors, clinical presentation, predict morbidity, mortality and provide guidelines for treatment in breast cancer. Aim: To evaluate the significance of breast cancer preoperative investigation when compared with apparently normal control. To assess the association of the significant preoperative investigations with the established breast cancer risk factors, clinical findings and histopathological prognostic factors. Materials and Methods: This was a case-control retrospective study with 156 histopathologically confirmed breast cancer cases and 102 controls and data were collected through structured questionnaire that included risk factors, clinical, histopathologic, and investigation details. Descriptive statistics, Pearson’s chi-square, Odds ratio, Student’s t-test and ANOVA were calculated. Results: There were 3 (1.9%), 81 (51.9%) and 72 (46.2%)cases of Grade I, II and III respectively. When compared to apparently normal controls haemoglobin (Hb), RBC, ESR, RBS, Urea, Creatinine, Sodium, Potassium and Chloride levels were statistically significant. On analysing these significant presurgical investigations with the established breast cancer risk factors, clinical findings and histopathological prognostic factors it was found that Hb with grade; WBC with stage; urea with lymphadenopathy and nipple discharge; creatinine with in-situ and Lymphovascular Invasion (LVI); sodium with grade, mobility of breast lump, lymph node metastasis and Progesterone Receptor (PR); potassium with in-situ had significant association. Radiological parameters were not statistically significant. Conclusion: The results obtained indicate that the presence of preoperative anaemia, leukocytosis and renal impairment has adverse influence in breast cancer and thereby aid to plan the treatment accordingly.
Authors and Affiliations
TS Rekha, Smriti Bhargava
Keywords
Related Articles
- EP ID EP582478
- DOI 10.7860/JCDR/2019/40314.12726
- Views 109
- Downloads 0
Evaluation of Masood’s and Modified Masood’s Scoring Systems in the Cytological Diagnosis of Palpable Breast Lump Aspirates
Introduction: Fine Needle Aspiration Cytology (FNAC) has a leading role in the assessment of breast lesions. Masood’s Scoring Index (MSI) and its modification (Modified Masood’s scoring index; MMSI) has been proposed to...
Fused Eyelids at Birth
Images in Medicine
Cu-sil Denture- A Space Maintainer for Function- In Paediatric Patients
The purpose of this report is to introduce Cu-sil like denture as a functional space maintainer. Here, we report two paediatric cases treated with Cu-sil like denture with multiple edentulous spaces and partially erupted...
Imaging in a Case of Extensive Paediatric Mediastinal Lymphoma Presenting as Haemothorax
ABSTRACT Lymphomas are the third most common paediatric malignancies and the most common paediatric mediastinal masses. On imaging they present as large, lobulated, homogenous, predominantly anterior mediastinal masses w...
Rigid Bronchoscopy and Jet Ventilation in Foreign Body Aspiration in A Two-Year-Old Female: A Case Report
ABSTRACT Foreign body aspiration is a leading cause of mortality in children of age group 1-3 years and presents significant challenges to the anaesthesiologist in maintaining oxygenation and ventilation while there is i...