Preoperative Factors Related to Stage and Grade Increase in D’Amico Low-Risk and Intermediate-Risk Group Patients

Journal Title: Üroonkoloji Bülteni - Year 2016, Vol 15, Issue 4

Abstract

Objective: In this study we searched preoperative factors that may cause upstaging and upgrading at D’Amico low-risk and intermediate-risk group patients who underwent radical prostatectomy (RRP) due to prostate adenocarcinoma. Materials and Methods: Among patients undergoing RRP retrospective evaluation, those who have PSA<10ng/mL, prostate needle biopsy (PNB) Gleason score (GS) ≤6 and clinical T1c-T2a were placed in the low-risk group. Patients with PSA 10-20 ng/mL and/or PNB GS=7 and/or clinical T2b were placed in the intermediate-risk group. In accordance with PNB GS and clinical stage, patients whose RRP GS and T stage increased or not with PNB GS 3+4=7 (7a) and RRP GS 4+3=7 (7b) were assessed as upgrade. The PSA data, PNB and RRP pathological data and biochemical recurrence rates of patients were investigated. Current data were used to separately assess and compare low-risk and intermediate-risk groups according to upstaging and upgrading. Results: Among the 151 patients in the low-risk group, it was identified that 21 had upstage and 63 had upgrade, while in the 187 patients in the intermediate-risk group 84 had upstage and 39 had upgrade. In the low-risk group, the PNB tumor percentage was identified to be high in the upgrade group (p<0.001). In the intermediate-risk group, PSA, PSA density, PNB perineural invasion (PNI) positivity, tumor percentage and positive core numbers were high in the upstage group. However, in the intermediate-risk group PSA, fPSA, PSA density, PNB GS and tumor percentage were high in the upgrade group (p<0.05). When postoperative factors were examined, tumor volume and surgical margin positivity were observed to be correlated with upstaging and upgrading. Conclusion: In conclusion, in the low-risk group PNB tumor percentage was related to upgrading, in the intermediate-risk group, PSA, PSA density and PNB tumor percentage were correlated with both upstaging and upgrading, while PNB PNI positivity and positive core numbers were observed to be correlated with T stage increase only.

Authors and Affiliations

Serdar Çelik, Ozan Bozkurt, Ömer Demir, Burçin Tuna, Kutsal Yörükoğlu, Güven Aslan

Keywords

Related Articles

A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome

Persistent Müllerian duct syndrome is a rare form of pseudohermaphroditism. This article is made of two case reports showing malignant transformation. The first case was a 36-year-old male who presented with infertility....

Organ-Preserving Approach in Bladder Cancer: Assessment of the Current Situation

Intravesical bacillus Calmette-Guerin (BCG) therapy is the gold standard treatment option in high-risk non-invasive bladder cancer. However, BCG is a very toxic agent. A significant proportion of patients have BCG intole...

Positron Emission Tomography in Renal Cell Carcinoma

Renal cell carcinoma is the most common solid kidney tumor. Conventional methods such as computed tomography and magnetic resonance imaging are usually chosen for diagnosis, staging, and evaluating recurrence and treatme...

The Prostatic Urethral Lift Method: A New Minimally Invasive Modality as an Alternative in the Treatment of Benign Prostatic Hyperplasia

Improvements in the treatment of benign prostatic hyperplasia (BPH), which is the most common cause of lower urinary tract symptoms in aging males, are proceeding progressively. The prostatic urethral lift procedure offe...

What is the Color of Cancer?

Objective: To investigate the colors that evokes cancer in the patients with prostate, lung and breast cancer, and in healthy controls. Materials and Methods: A visual card in one of the 9 colors (white, red, orange, ye...

Download PDF file
  • EP ID EP228358
  • DOI 10.4274/uob.738
  • Views 88
  • Downloads 0

How To Cite

Serdar Çelik, Ozan Bozkurt, Ömer Demir, Burçin Tuna, Kutsal Yörükoğlu, Güven Aslan (2016). Preoperative Factors Related to Stage and Grade Increase in D’Amico Low-Risk and Intermediate-Risk Group Patients. Üroonkoloji Bülteni, 15(4), 148-153. https://europub.co.uk/articles/-A-228358