Preoperative Levels of Serum Total Antioxidants and Sialic Acid in Leiomyoma: A Case Control Study
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 4
Abstract
Background: The exact cause of leiomyoma which affects at least 5 million women throughout the world is not known. Currently there are only few markers for leiomyoma which includes serum protein, prolactin, CA 125, soluble serum HLA-G, vascular endothelial growth factor and lactate dehydrogenase etc. However a reliable marker is still not found. This study is undertaken to analyse the association of oxidative stress and sialic acid in leiomyoma patients compared with control group. Methods: This non interventional cross sectional study comprised of 50 study subjects with 25 leiomyoma patients (case group) and 25 healthy individuals (control group). Total antioxidant was estimated by phosphomolybdenum method. Serum sialic acid was measured by using diphenylamine method. Results: The result showed a significant increase in the sialic acid level in leiomyoma patients (80.51±9.61) in comparison with normal healthy individuals (57.73±7.77) with p=0.05. Also an insignificant correlation of Total antioxidant level [TAC] between case and control group (p= 0.591). Conclusion: In conclusion, serum sialic acid concentration is significantly increased in leiomyoma patients as compared to healthy control. This suggests a probable clinical use of sialic acid evaluation in future as a marker of leiomyoma. An insignificant correlation between total antioxidant and leiomyoma can be due to less involvement of oxidative stress in the pathogenesis of leiomyoma.
Authors and Affiliations
Kishan Prasad H. L
Keywords
Related Articles
- EP ID EP521174
- DOI 10.21088/ijprp.2278.148X.7418.21
- Views 77
- Downloads 0
A Histopathologic Study of Connective Tissue Diseases of Skin
Cutaneous involvement is a prominent feature in connective tissue disease and the skin lesions are extremely important in diagnosing and subclassifying patients with these conditions. Fifty cases of connective tissue dis...
Fine Needle Aspiration Cytology of Palpable Breast Lump: A Study of 2 Years
Obective: Breast lumps constitute a significant proportion of surgical cases in women of both developed and developing countries. It is needed to distinguish benign lumps from malignant preoperatively for definite treatm...
Comparison of Various Staining Methods to Detect Helicobacter Pylori
Context: Helicobacter pylori (H. pylori) is the major cause of chronic gastritis, peptic ulcer and gastric cancer. It causes varied histological derangements & hence the detection of H. pylori is important. Aims: The stu...
Histomorphological Spectrum of Prostatic Lesions in TURP and Needle Biopsies
Introduction: Transurethral resection of prostate and prostatic biopsies are very common specimens in surgical pathology. Prostatic biopsies are done in cases where there is clinical suspicion of malignancy. These specim...
Histopathological Spectrum of Skin Biopsies: A One Year Retrospective Study
Introduction: Skin is involved in a number of pathological conditions and affects all age groups and both the sexes, ranging from mild to severe skin problems such as dry skin,wrinkling ,disfigurement ,itching, painful a...