PREPAPATION AND EVALUATION OF VALSARTAN LOADED HYDROGEL BEADS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
Valsartan loaded gel beads were prepared using sodium alginate, sodium carboxy methyl cellulose and chitosan individually using cross linking agent and chitosan along with sodium alginate/sodium carboxy methyl cellulose by ionotropic gelation method. The prepared gel beads were enteric coated using ethyl cellulose by solvent evaporation. The preformulation study performed on combination of drug with polymers by Fourier-transform infrared spectroscopy suggested that drug and polymers were compatible. The surface morphology was studied by scanning electron microscopy revealed that spherical or disc shape hydrogel beads were formed with smooth/rough texture. All the prepared hydrogel beads were evaluated for particle size, drug entrapment efficiency and percentage yield. The mean particle size was between 560.23-869.47 µm and increased as the concentration of polymers was increased. The drug entrapment efficiency was more than 90%. All the hydrogel beads were evaluated for invitro swelling and invitro release study. All the hydrogel beads showed good swelling in phosphate buffer 6.8 pH up to 8 h maintaining the integrity of the formulation. The swelling index followed the rank order sodium carboxy methyl cellulose<sodium alginate<chitosan and also as the concentration of polymer increased there was decrease in swelling. The invitro release of valsartan from all the hydrogel beads was more than 80% extended up to 10h in a nearly controlled manner. The invitro release followed the same pattern of swelling and decreased as the concentration of polymer increased. Hence it could be concluded that valsartan enteric coated hydrogel beads prepared by using combination of chitosan along with sodium alginate and sodium carboxy methyl cellulose sustain the release of valsartan more than 10 h in a predetermined manner for the effective management of hypertension.
Authors and Affiliations
M. A Saleem. , YD Murali , MD Naheed , Jaydeep Patel , Dhaval Malvania
Keywords
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