Abstract

The Pyrimidone derivatives say, N arylidine 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidonecarbohydrazides 2a e were synthesized by condensation of Benzaldehyde derivatives with 6 Methyl 2 oxo 4 phenyl 1,2,3,4 tetrahydro pyrimidone carbohydrazides 1 in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidone 5 carboxamido 5 oxo 2 aryl pyrrolidine 3 carboxylic acid 3a e . These 3a e on Mannich reaction with formaldehyde and morpholine offered 2 aryl 1 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamido 4 morpholinomethyl 5 oxopyrrolidine 3 carboxylic acid 4a e . Further 4a e on condensation with 1, 2 benzenediamine yield N 3 1H benzo d imidazol 2 yl 2 aryl 4 morpholinomethyl 5 oxopyrro lidin 1 yl 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamide 5a e . Their structures were confirmed by elemental contents and spectral features. The antimicrobial activities of all three series have also been evaluated. The whole synthetic route is shown below. by Pranay Shah | R. I. Patel | P. J. Vyas "Preparation and Biological Screening of Novel Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd22815.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/22815/preparation-and-biological-screening-of-novel-heterocyclic-compounds/pranay-shah

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