PREPARATION AND CHARACTERIZATION OF GLICLAZIDE SOLID DISPERSION IN BINARY AND TERNARY SYSTEM

Abstract

Objective: The objective of this research was to improve the dissolution rate of gliclazide by solid dispersion technique with poloxamer 188, HPMC, and Eudragit® E100 as carriers.Methods: Solid dispersions were prepared by solvent evaporation methods in the binary and ternary system. In binary system gliclazide was mixed with poloxamer188 in the ratio of 1:0.5, 1:0.75, 1:1, 1:1.5 and 1:2, with HPMC in the ratio of 1:0.1, 1:0.125, and 1:0.25, and with Eudragit® E100 in 1:0.25 ratio. In ternary system gliclazide was prepared with poloxamer188 and HPMC in the ratio of 1:2:0.1 and 1:2:0.25, and with poloxamer188 and Eudragit® E100 in the ratio of 1:1:0.25 and 1:2:0.25. Pure gliclazide, solid dispersions, and physical mixtures were characterized by dissolution testing, DSC, FTIR, dan XRD.Results: At the 15th minute, the highest dissolution rate observed from binary and ternary solid dispersions of gliclazide were from gliclazide-poloxamer188 1:2 dan gliclazide-poloxamer188 and Eudragit® E100 1:2:0,25 which showed 12 and 15 fold increase in dissolution rate compared by pure gliclazide. The decrease of endothermic peak (DSC) and the intensity of the diffraction pattern by XRD of solid dispersions showed the decrease of crystallinity rate. Characterization by FTIR virtually showed no shift of absorption peaks of gliclazide on solid dispersion.Conclusion: The results of this study indicate that the solid dispersion of gliclazide using poloxamer and Eudragit®E100 in 1:2:0, 25 ratio of weight was the best in enhancing the dissolutions characteristics and bioavailability.

Authors and Affiliations

Wardiyah Sunaryo Prawiro, Sukmadjaja Asyarie, Saleh Wikarsa

Keywords

Related Articles

IMPLEMENTATION OF QBD APPROACH TO DEVELOP AND VALIDATE ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF DULOXETINE HYDROCHLORIDE AND METHYLCOBALAMIN IN PHARMACEUTICAL DOSAGE FORM BY HPTLC METHOD

Objective: To develop and validate High-Performance Thin Layer Chromatography (HPTLC) analytical method for the determination of Duloxetine Hydrochloride (DUL) and Methylcobalamin (MEC) in the standard mixture and pharma...

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR QUANTIFICATION OF FLUNISOLIDE IN NASAL SPRAY FORMULATION BY RP-HPLC

Objective: The objective of the present research work was to develop and validate reversed-phase high-performance liquid chromatography (RP-HPLC) method for quantification of flunisolide in nasal spray formulations.Metho...

MOLECULAR DYNAMICS STUDY OF NON-HYDROGEN-BONDING BASE-PAIR DNA DUPLEX d(GTCDNAM GCGCCGTGGC). d(GCCACGGCGCD5SICSGAC)

Objective: The objective of the study was to elucidate the structural activity of a natural DNA sequence modified by a hydrophobic base-pair which didn’t form Watson-Crick (W-C) hydrogen-bond. The modified unnatural ba...

CYTOPROTECTIVE EFFECT OF OCIMUM EXTRACT ON INJURED RENAL EPITHELIAL CELLS

Objectives: Renal cell injury is one of the important factors affecting urolithiasis. Crystals which aggregate to constitute the kidney stones are formed in the supersaturation condition in kidney. Reactive oxygen specie...

UV SPECTROPHOTOMETRIC DETERMINATION OF RUPATADINE FUMARATE IN BULK AND TABLET DOSAGE FORM BY USING SINGLE POINT STANDARDIZATION METHOD

Objective: To develop and validate a simple, selective, precise and accurate method for the estimation of rupatadine fumarate in bulk and tablet dosage form by using the single point standardization method as per interna...

Download PDF file
  • EP ID EP576160
  • DOI -
  • Views 64
  • Downloads 0

How To Cite

Wardiyah Sunaryo Prawiro, Sukmadjaja Asyarie, Saleh Wikarsa (2016). PREPARATION AND CHARACTERIZATION OF GLICLAZIDE SOLID DISPERSION IN BINARY AND TERNARY SYSTEM. International Journal of Pharmacy and Pharmaceutical Sciences, 8(8), 363-368. https://europub.co.uk/articles/-A-576160