PREPARATION AND CHARACTERIZATION OF GLICLAZIDE SOLID DISPERSION IN BINARY AND TERNARY SYSTEM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: The objective of this research was to improve the dissolution rate of gliclazide by solid dispersion technique with poloxamer 188, HPMC, and Eudragit® E100 as carriers.Methods: Solid dispersions were prepared by solvent evaporation methods in the binary and ternary system. In binary system gliclazide was mixed with poloxamer188 in the ratio of 1:0.5, 1:0.75, 1:1, 1:1.5 and 1:2, with HPMC in the ratio of 1:0.1, 1:0.125, and 1:0.25, and with Eudragit® E100 in 1:0.25 ratio. In ternary system gliclazide was prepared with poloxamer188 and HPMC in the ratio of 1:2:0.1 and 1:2:0.25, and with poloxamer188 and Eudragit® E100 in the ratio of 1:1:0.25 and 1:2:0.25. Pure gliclazide, solid dispersions, and physical mixtures were characterized by dissolution testing, DSC, FTIR, dan XRD.Results: At the 15th minute, the highest dissolution rate observed from binary and ternary solid dispersions of gliclazide were from gliclazide-poloxamer188 1:2 dan gliclazide-poloxamer188 and Eudragit® E100 1:2:0,25 which showed 12 and 15 fold increase in dissolution rate compared by pure gliclazide. The decrease of endothermic peak (DSC) and the intensity of the diffraction pattern by XRD of solid dispersions showed the decrease of crystallinity rate. Characterization by FTIR virtually showed no shift of absorption peaks of gliclazide on solid dispersion.Conclusion: The results of this study indicate that the solid dispersion of gliclazide using poloxamer and Eudragit®E100 in 1:2:0, 25 ratio of weight was the best in enhancing the dissolutions characteristics and bioavailability.
Authors and Affiliations
Wardiyah Sunaryo Prawiro, Sukmadjaja Asyarie, Saleh Wikarsa
Keywords
Related Articles
- EP ID EP576160
- DOI -
- Views 65
- Downloads 0
EFFECT OF MENTHA PIPERATA IN EXPERIMENTAL PROSTATIC HYPERPLASIA IN WISTAR ALBINO RATS
Objective: To investigate the protective efficacy of Mentha piperata in experimental benign prostatic hyperplasia in Wistar albino rats.Methods: Benign hyperplasia of prostate was induced by subcutaneous injection of t...
IN VITRO AND IN SILICO ANTIOXIDANT ACTIVITY OF PURIFIED FRACTIONS FROM PURPLE SWEET POTATO ETHANOLIC EXTRACT
Objective: Purple sweet potato (Ipomoea batatas L.) contains antioxidant compounds like anthocyanins (cyanidin and peonidin). Therefore, the current study was conducted to obtain anthocyanins fractions from purple sweet...
PHARMACY PRACTICE EXPERIENTIAL PROGRAMS IN THE CONTEXT OF CLINICAL EDUCATION
Objective: To identify studies describing and/or assessing pharmacy practice experiential programs focusing on clinical education.Methods: A systematic literature review was carried out. The databases searched included L...
ACETYLENIC DIMERIZATION UNDER BASIC CONDITIONS
Objective: The lack of information concerning the pharmacological activity of amino acetylenic amide derivatives in which the cyclic amine is aziridine or azetidine promoted our interest to synthesize N-[4-(1-azeridinyl)...
ANTIOXIDANT STUDIES ON METHANOL AND AQUEOUS EXTRACTS OF GYMNOSPORIA MONTANA PLANT
Objective: The main objective of this study was to evaluate the free radical scavenging activity of methanol (70%) and aqueous extract of G. montana leaves which is a traditionally used herb known for its hepatoprotectiv...