Preparation and Characterization of Phytosomal-Phospholipid Complex of P. Amarus and its Tablet Formulation
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2013, Vol 1, Issue 1
Abstract
Present investigation was aimed at formulation, characterization and evaluation of phytosomal complex tablets for sustained delivery of Phyllanthus amarus complex. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane −ethyl acetate solvent mixture. It was obtained in high yields (1.23%), compared to reported procedures and the purity was ascertained by HPTLC analysis. Phyllanthin was characterized for M.P, UV −Visible spectrophotometry, FT-IR, 1H NMR, 13C and NMR analysis. Release kinetics was evaluated by using United States Pharmacopeia (USP)-22 type I dissolution apparatus. Scanning electron microscopy was used to visualize the effect of dissolution medium on matrix tablet surface. HPTLC was carried out for quantitative and qualitative estimation of Phyllanthin in Phyllanthus amarus and Rf of phyllanthin was found to be about 0.25. The content was found to be maximum for phytosomal complex of phyllanthus formed by vaccum drying of 1:1 drug excipient ratio. The in-vitro drug release study revealed that optimized formulation sustained the drug release for 12 hr (88.1% ± 4.1% release). Fitting the in vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.
Authors and Affiliations
Sandeep Arora , Arvind Sharma , Parneet Kaur
Keywords
Related Articles
- EP ID EP596667
- DOI 10.15415/jptrm.2013.11001
- Views 219
- Downloads 0
Assessment for Sporicidal Activity of Two Types of Peroxygen/Silver-Based Disinfectants: A Comparative Study
Numerous cases have been reported globally showing outbreaks, dissemination of infections and/or spoilage of medicinal products, food and other consumables that affects human life and may lead to death in some cases. One...
Analgesic Activity of some 1-Phenyl-3-aryl-5- (4-(butanoloxy) phenyl) 1H-pyrazoles
A series of analgesic activity of synthesised 1 -Phenyl-3-aryl- 5-(4-(butanoloxy) phenyl) 1H-pyrazoles were synthesized from chalcones and screened for their in vitro analgesic activity. Chalcones i.e.,1-aryl-3- (4-hydro...
Analytical Review on Raloxifene -An Estrogen Receptor Modulator in Different Pharmaceutical Formulations and Biological Fluids
Raloxifene (RLX) is an oral selective estrogen receptor modulator (SERM). It is showing estrogenic action on bone and anti-estrogenic action on uterus and breast. An extensive literature has been published for analysis o...
Antiamnesic Activity of Extracts and Fraction of Desmodium Gangeticum
Desmodium gangeticum D.C. (Salpani; family – Papilionaceae) has been traditionally used in the treatment of various ailments especially in dementia. Thus, it was planned to screen antiamnesic activity of D. gangeticum to...
Cold Chain: A Lynchpin of National Immunization Program
Cold chain management (CCM), a lynchpin of National Immunization Program (NIP) is to deliver the vaccines or other immunological products/ vaccines to right people, at right place, and in right time ineffective m...