Preparation and Characterization of Polymeric Mucoadhesive Film for Buccal Administration
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 4
Abstract
Objectives: Buccal films consist mainly of polymer that has a good mucoadhesive profile and plasticizer. A lot of polymers and plasticizers can be used to configure the mucoadhesive films as hydroxyethyl cellulose and glycerin respectively. Material and Methods: Films prepared by dispersing the polymer, mixing it with plasticizer and pouring it in Petri dishes to be dried and cut finally. Physicochemical tests were used to evaluate the films. These tests are organoleptic evaluation and polymer and plasticizer selection, determination of rheological properties of polymers, film thickness, and determination of moisture content, determination of moisture uptake and evaluation of mechanical properties. Results and Conclusions: It was found that films prepared from polyvinyl alcohol 2% (w/w) especially with the addition of propylene glycol 20% from the weight of the polymer have excellent characteristics. This formula has promising organoleptic and mechanical properties and its solution is Non-Newtonian pseudoplastic. Moreover, this formula is very thin and has moderate percent of moisture content and moisture uptake. Also, it has high elongation with moderate tensile strength. As a result, it is better to prepare the film by these ingredients to obtain an ideal mucoadhesive formula.
Authors and Affiliations
Ramy B. Gales, Hassan M. Ghonaim, Ahmed R. Gardouh, Mamdouh M. Ghorab, Sabry S. Badawy
Keywords
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- EP ID EP344731
- DOI 10.9734/BJPR/2014/5399
- Views 108
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