Abstract

The present work deals with the preparation of Tolterodine tartrate proniosome formulations by ether injection method by using different surfactants in different ratios. The prepared proniosomal formulation were evaluated for vesicle size, rate of spontaneity, encapsulation efficiency, drug content etc. In vitro release study was conducted and it indicated that, increases in liphophilicity of surfactants decreases release of Tolterodine tartrate from proniosomal formulations. Stability studies were performed at optimized formulation PG4, indicated that, the prepared formulations remain stable at room and refrigeration temperature.

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