Preparation and Evaluation of Imiquimod Loaded Liposomal Dispersion: Part-I
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 2
Abstract
The aim of present investigation was to encapsulate Imiquimod into liposomes and optimization of process and formulation variables, characterization of liposome with respect to shape, lamellarity, drug entrapment efficiency to opt maximum efficacy and to reduce side effects. Preliminary work like development of suitable analytical method, preparation of Calibration curve, Melting point, Partition coefficient, Permeability coefficient determinations, Physicochemical compatibility of Imiquimod and excipients like phospholipid and cholesterol were carried out and results were reported and used for the further work. Liposomes were prepared by thin film hydration technique. Various process parameters like Vacuum of 25 inch Hg, 100 rpm, 2 hour time of hydration, 50 ºC temperature, Drug : Soya Lecithin : Cholesterol ratio 1:12:2, aqueous phase: organic phase ratio1:3 gave thin, smooth, uniform and translucent film with higher percent drug encapsulation efficiency.
Authors and Affiliations
Mr. Tanmay N. Patel*| Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Dr. Madhabhai M. Patel| Shankersinh Vaghela Bapu Institute of Pharmacy, Gujarat Technological University
Keywords
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