PREPARATION AND EVALUATION OF IRBESARTAN-CYCLODEXTRIN INCLUSION COMPLEXES
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
In the present work effect of methyl-β-cyclodextrin (MβCD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MβCD were prepared in 1:1 molar ratio by various methods. Complexes were characterized using Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that IRB can form inclusion complex with MβCD. The dissolution profiles of inclusion complexes were compared with those of IRB alone and the physical mixture. The dissolution rate of IRB was increased remarkably by MβCD inclusion complexation.
Authors and Affiliations
Rajashree Hirlekar
Keywords
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