PREPARATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF DROTAVERINE HYDROCHLORIDE USING SUBLIMATION TECHNIQUE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 5
Abstract
Objective: To formulate orally disintegrating taste masked tablets of drotaverine hydrochloride (HCl) by sublimation technique.Methods: Initially superdisintegrant was selected and its concentration was optimized by pre-compression and post-compression parametric evaluation. Camphor and menthol were used as sublimating agents alone and in combination to mask the taste of drotaverine hydrochloride. Prepared tablets were evaluated for physicochemical evaluation, in vitro dissolution studies and fourier transformation-infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry studies.Results: The optimised formulation DCM2 prepared with a mixture of camphor and menthol was characterised by fourier transformation-infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry studies and found no incompatibility and no major shifts were noticed.Conclusion: The results demonstrated that the prepared drotaverine HCl orally disintegrating tablets showed better taste masking. The present sublimation technique can be effectively used for taste masking and also for orally disintegrating tablets.
Authors and Affiliations
Kuralla Hari, Saripilli Rajeswari, Kolapalli Venkata Ramanamurthy
Keywords
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- EP ID EP567504
- DOI 10.22159/ijpps.2018v10i5.24503
- Views 114
- Downloads 0
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