Preparation and Evaluation of Sustained Release Matrix Tablet of Diclofenac Sodium using Natural Polymer
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 6
Abstract
Sustained release tablets of Diclofenac Sodium were fabricated using Cashew nut tree gum, HPMC and Carbopol. The tablets were evaluated for preformulation studies like angle of repose, bluk density, compressibility index and physical characteristics like hardness, weight variation, fraibilty and drug content. In-vitro release of drug was performed in PBS pH 7.2 for twelve hours. All the physical characters of the fabricated tablet were within acceptablelimits. The tablet with HPMC(Batch B-I) and Carbopol(Batch C-I) exhibited greater drug content than those with cashew nut tree gum and other batches of HPMC and carbopol. A better sustained drug release (50.65%) was obtained with the matrix tablet (Batch C-III) made-up of the carbopol than with the cashew nut tree gum and HPMC. It is cleared through the dissolution profile of Diclofenac sodium from matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent
Authors and Affiliations
G. N. K. Ganesh , R. Sureshkumar , N. Jawahar , V. Senthil , D. Nagasamy Venkatesh , M. Shanmukha Srinivas
Keywords
Related Articles
- EP ID EP139624
- DOI -
- Views 119
- Downloads 0
Synthesis of novel piperazine and morpholine linked substituted<br /> pyrimidine derivatives as antimicrobial agents
Several 6-(substituted)-5-cyano-2-thiouracils 1a-d, were prepared by the condensation of different aldehydes with ethylcyanoacetate and thiourea through a single step reaction by conventional and microwave irradiation te...
UV-Spectrophotometric Methods for Determination of Aceclofenac and Diacerein in Pharmaceutical Formulation
Three simple, specific, reproducible methods have been developed and validated for the simultaneous estimation of Aceclofenac and Diacerein in pharmaceutical formulation by UV-Spectrophotometric methods viz; Method I, Ab...
The relationship between Osmolarity and Osmolality of Infusion Solutions of Monosaccharides
Concentration of Osmotically active solutes plays a key role in an acceptance of parenteral infusions by patients. It is generally recommended that labels of infusions should list osmolarity (osmol/l). However, osmometer...
Improvement of Solubility and Dissolution of Indomethacin by Liquisolid and Compaction Granulation Technique
The purpose of this study was to develop novel techniques to enhance the dissolution rate of poorly watersoluble drugs substance Indomethacin (IM).The granules of IM were prepared by nonaqueous liquisolid andc...
Antioxidant properties and in vitro immunomodulatory effects of peppermint (Mentha x piperita l.) Essential oils in human leukocytes
Peppermint (Mentha x piperita L.) is popular in folk medicine. Its immune effects however received so far limited attention. In the present study, peppermint oils from two cultivars (RAC 541 and Laimburg) grow...