PREPARATION AND IN-VITRO EVALUATION OF DESLORATADINE FLOATING TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: Desloratadine is histamine H1 – receptor antagonist used in treatment of allergic and rhinitis conditions. The tablets were prepared by direct compression technique,using polymers such as Carbopol 934P,Carbopol 940P either alone or combination and other excipients such as NaHCO3,citric acid, mannitol, avicel pH 102, SDL.Methods: The prepared tablets were evaluated in terms of their physical properties, hardness, % friability, weight variation, content uniformity, drug-excipient compatibility (FTIR), in-vitro release, floating properties and swelling index. Result shows that as amount of carbopol 934P increased the drug release decreased due to increase penetration of water in to polymer. It was found that increase sodium bicarbonate concentration cause an increase in the floating time (FLT) were also increased drug release while floating time was decreased due to decrease in matrix coherent.Mannitol showed the best release properties as a diluent when compared with Avicel pH 102 and SDL the drug release was accelerated.Results: Swelling index studies of selected formula (F9) 96% compared with other formulas gave rapid release of desloratadine that indicated a combined effect of both diffusion and erosion mechanisms on drug release from floating dosage form.Conclusion: The stability of the selected formula (9) was also studied at different temperatures (40, 50 and 60oC) for three months and the calculated shelf life data was found to be about 2.7 years.Â
Authors and Affiliations
Hiba Master Pharma, Balkis Ahmed Kamal
Keywords
Related Articles
- EP ID EP579553
- DOI -
- Views 78
- Downloads 0
CHEMICAL COMPOSITIONS, ï¡-AMYLASE INHIBITORY AND ANTIOXIDANT ACTIVITIES OF THE ESSENTIAL OILS FROM UNRIPE FRUIT PULP AND LEAVES OF SYZYGIUM CUMINI
Objective: To investigate chemical compositions, a-amylase inhibitory and antioxidant capacity of the essential oils from the unripe fruit pulp and leaves of a traditional medicinal plant Syzygium cumini.Methods: The ess...
EFFICACY OF PHARMACOLOGICAL AGENTS IN THE TREATMENT OF TEMPOROMANDIBULAR JOINT DISORDER: A SYSTEMATIC REVIEW
The  aim of this article is to analyse the effectiveness of pharmacological agents for treatment of Wilke’s disease, anterior disc displacement without reduction, post arthroscopy TMJ pain, and internal disc derangeme...
INDUCTION OF APOPTOSIS BY FATTY ACID RICH FRACTION OF SOLANUM NIGRUM ON CERVICAL CANCER CELL LINES
Objective: Mechanism of cell death inducing pathway of chloroform fraction of methanolic extract of Solanum nigrum were studied in a panel of cervical cancer cell line.Methods: Cells were treated with IC50 doses (previou...
FORMULATION AND EVALUATION OF AN HERBAL ANTI-INFLAMMATORY GEL CONTAINING TRIGONELLA FOENUM GREACUM SEED EXTRACT
Objective: The present study was aimed to develop topical gel containing Trigonella foenum greacum (fenugreek) seed extract using carbopol-934, Hydroxypropyl methylcellulose K4M (HPMC K4M) as gelling agents and to invest...
IN VITRO EVALUATION OF ANTIOXIDANT CAPACITY OF ALGERIAN ORIGANUM PLANT BY SPECTROPHOTOMETRICAL AND ELECTROCHEMICAL ASSAYS
Objective: The aim of the present study was to evaluate the antioxidant capacity and total phenolic of ethanolic extracts of two plants; Origanummajoranaand Origanumvulgare.Methods: Total phenolic was estimated by the Fo...