PREPARATION AND IN VITRO EVALUATION OF ORAL LIPOSPHERE OF CANDESARTAN CILEXETIL
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
Liposphere was prepared by melt dispersion method. At first Lipid phase lipids (eg; glycerylmonostearate (GMS), Compritol 888, Precirol ATO 5, stearic acid, Dynasan 116) and drug was taken in a beaker and was melted at 70°C while stirring. A drop of lipospheres dispersion was spread on a glass slide and examined under the digital microscope (40X) to determine the size and shape of Particles. Scanning Electron Microscope (Model: JSM 5200, Japan) was used to characterize surface morphology of optimized Candesartan cilexetilliposphere. Zeta potential of the liposphere was determined by Malvern Nano Zetasizer instrument. Sample was scanned by FTIR under the range of 400-4000 cm-1. The amount of Candesartan cilexetil present in lipospheres was determined by taking suspension in an Eppendorf and centrifuged at 15000 rpm for 30 min. and 1 ml of supernatant was taken and diluted with methanol and absorbance was measured at 256 nm by UV Spectrophotometer. The release of drug from lipospheres was determined in a USP type-I dissolution apparatus. A weighed amount of lipospheres equivalent to 32 mg drug were filled in capsule and then placed in the dissolution test apparatus. The release kinetic was studied by various kinetic models as zero order plot, first order plot, higuchi plot and korsmeyer-peppas.
Authors and Affiliations
Madhukanwar Rathore
Keywords
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