Preparation and In Vitro, In Vivo Evaluation of Clarithromycin Microcapsules
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2011, Vol 2, Issue 1
Abstract
PURPOSE: To develop and validate a method to prepare clarithromycin (CLM) microcapsules to mask the bitter taste and provide effective treatment, and evaluate the quality of microcapsules in detail, especially the in vitro and in vivo pharmacokinetics behavior. METHODS: CLM microcapsules were prepared using ethyl cellulose as matrix material by an emulsion solvent diffusion method. The physicochemical property, in vitro release study, sensory test and stability test were evaluated. Self-made CLM dry suspension or conventional tablets containing 250 mg of CLM were orally administered with 250 mL of water. The plasma concentration was determined and the pharmacokinetic parameters were calculated by non-compartmental methods. RESULTS: Stable microcapsules could be prepared using ethyl cellulose as matrix material. The quality evaluation of prepared microcapsules was qualified, and the pharmacokinetic parameters of dry suspensions and conventional tablets were as following. Cmax were 1.32±0.62 and 1.40±0.58 μg•ml-1; Tmax were 3.51±0.54 and 2.01±0.42 h; AUC were 7.65±2.54 and 7.12±2.10 μg•h•ml-1. CONCLUSION: The preparation method is easy and applicable. The self-made CLM dry suspension containing microcapsules sufficiently alleviate the bitterness of commercial CLM dry suspension, but not decrease the bioavailability and have better effect for delaying drug release in healthy volunteers.
Authors and Affiliations
Liandong Hu, Wei Liu, Li Li, Jiqiang Zhao, Xun Yang
Keywords
Related Articles
- EP ID EP97800
- DOI -
- Views 164
- Downloads 0
Emergence of Multidrug Resistant Extended-Spectrum β-Lactamase Producing Eshcherichia coli Associated With Urinary Tract Infections in Bangladesh
The incidence of infections due to extended-spectrum β-lactamase (ESBL)–producing Escherichia coli has been increased dramatically in recent years. Treatment is difficult because of frequent multidrug resistance. To iden...
Novel Approaches in Formulation and Drug Delivery using Contact Lenses
The success of ocular delivery relies on the potential to enhance the drug bioavailability by controlled and extended release of drug on the eye surface. Several new approaches have been attempted to augment the competen...
A REVIEW OF ANTI-HYPERTENSION THERAPIES IN DIABETIC PATIENTS
The objective of this study was to review published articles on the issues surrounding tight blood pressure control in hypertensive diabetics.Relevant medical subject headings (MeSH) terms and keywords to review scientif...
ANTIHYPERGLYCEMIC EFFECT OF ETHANOLIC EXTRACT AND FRACTIONS OF ANACARDIUM OCCIDENTALE L. STEM BARK IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The numbers of adults with diabetes in the world is estimated to rise 300 millions in the year 2025 and this leads to increasing search for better anti-diabetic drug. The effects of the ethanol extract (1.25g/kg) and fra...
Antioxidant, Antihyperlipidaemic and Antidiabetic Activity of Eugenia Floccosa Bedd Leaves in Alloxan Induced Diabetic Rats
The ethanol extract of Eugenia floccosa Bedd (Family: Myrtaceae) leaf was investigated for its antioxidant, antihyperlipidaemic and antidiabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by admini...