Preparation of Aluminum Hydroxide by Precipitation Method for Vaccine Adjuvant Application
Journal Title: International Journal of engineering Research and Applications - Year 2017, Vol 7, Issue 11
Abstract
Aluminum hydroxide is commonly used as vaccine adjuvant. The adjuvant activity of aluminum hydroxide is considered to depend on its particle size. In order to obtain aluminum hydroxide with high adjuvant activity, we synthesized aluminum hydroxide at various particle sizes and investigate the effect of particle size on protein adsorption property. Aluminum hydroxide was synthesized by precipitation method at various agitation rates. The aluminum hydroxide product synthesis was identified by FTIR. Both and found peak on 595, 1634 and 3331 cm-1 that contributed to aluminum hydroxide. The size of aluminum hydroxide particles highly depends on agitation rate, in which higher agitation produce smaller particles. Particle size analyzer resulted 3422, 305 and 279 nm respectively for 200, 5000 and 10000 rpm agitation rate. The adsorption of protein using BSA as a model protein on aluminum hydroxide particles was carried out by mixing the particles in suspension with the protein in solution. The protein adsorption of BSA to the aluminum hydroxide nanoparticles was reach 90%.
Authors and Affiliations
Etik Mardliyati, Damai Ria Setyawati, Sabar Pambudi, Suryandaru . , Retno Kusumaningrum, M. Ikhlasul Amal
Keywords
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- EP ID EP392866
- DOI 10.9790/9622-0711052125.
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