PREPARATION OF SUSTAINED RELEASE CINNAMALDEHYDE MICROSPHERES AND ITS REPELLENT ACTIVITY AGAINST AEDES AEGYPTI
Journal Title: Acta Parasitologica et Medica Entomologica Sinica - Year 2024, Vol 31, Issue 4
Abstract
[Objective] This study aimed to prolong the duration of cinnamaldehyde's insect repellent activity and enhance its repellent potency. [Methods] Cinnamaldehyde microspheres were prepared using chitosan and gelatin as wall materials via layered self-assembly. The structure, morphology, particle size, encapsulation rate, and atomization efficiency of the microspheres were investigated using Fourier transform infrared spectrometry, scanning electron microscopy, laser particle size analyses, ultraviolet spectrophotometry, and a micropore piezoelectric ultrasonic atomizer. An efficacy test of the mosquito repellent was performed according to GB/T 13917.9-2009 and the effective protection time was recorded. [Results] Cinnamaldehyde was successfully encapsulated in spherical microspheres with an encapsulation rate of 65%. The average particle size was 1 613.7 nm and the droplet particle size was small. The atomization volume was large, and the middle diameter of the droplets was 23.57 μm. The repellent rate of 5% cinnamaldehyde was <50% in the 2nd hour and its repellent efficacy was poor. The repellent rates of the cinnamaldehyde microspheres were 100% in the 2nd hour and 82.64% in the 4th hour. [Conclusions] Slow-release cinnamaldehyde microspheres can mitigate the olfactory impact of cinnamaldehyde and extend its repellent activity against Aedes aegypti up to 2 h, offering insights into novel enhanced formulations for mosquito repellents.
Authors and Affiliations
Xi-hui YU, Ying-hua WU
Keywords
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- EP ID EP759144
- DOI 10.3969/j.issn.1005-0507.2024.04.003
- Views 35
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