Prescribing Patterns of Antiepileptic Drugs in Epilepsy Patients: A Picture from the Therapeutic Drug Monitoring Unit in a Medical Institute in Manipur
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Although epileptic seizures can be controlled with monotherapy in most cases, polytherapy is used for refractory cases. A number of studies have reported the prescription patterns of antiepileptic drugs in different parts of India. Such reports are lacking in Manipur. Therefore, the present study was planned to know prescribing patterns of antiepileptic drugs in epilepsy patients in Manipur. Material and Methods: A retrospective cross-sectional analysis of prescriptions of epilepsy patients attending Therapeutic Drug Monitoring (TDM) unit in the Regional Institute of Medical Sciences, Imphal, Manipur was planned. Prescriptions of 65 epilepsy patients attending TDM unit during November, 2013 to January, 2017 were analysed with respect to demographic profiles, seizures types and number of drugs prescribed. Results were expressed in percentages. Results: Out of 65 patients, 64.61% were males. Undetermined seizures were 35.38% followed by generalised tonic clonic seizure (26.15%), complex partial seizures (21.54%), secondarily generalised (12.31%) and simple partial seizures (4.61%) respectively. Two drugs combinations were found in 38.46% followed by 1 drug treatments (35.38%), 3 drugs (16.92%) and 4 drugs combinations (9.23%) respectively. Most commonly prescribed drugs were Oxcarbazepine in monotherapy (47.83%), Oxcarbazepine with Clobazam in 2 drugs combinations (36%), Oxcarbazepine, Clobazam with Levetiracetam in 3 drugs combinations and Oxcarbazepine, Phenobarbitone, Levetiracetam and Divalproex in 4 drugs combinations (33.33%). Conclusion: Newer antiepileptic drugs were more frequently prescribed. Oxcarbazepine topped the list of prescriptions followed by Clobazam and Levetiracetam. Two drugs combination treatment was the commonest approach followed by monotherapy.
Authors and Affiliations
Ngangom Gunindro, Sania Monica Kholi, Yumnam Sarita Devi, Leishangthem J oshila, N. Hemantakumar, Krishna Pramodini Devi
Keywords
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