Prescribing Patterns of Antiepileptic Drugs in Epilepsy Patients: A Picture from the Therapeutic Drug Monitoring Unit in a Medical Institute in Manipur
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Although epileptic seizures can be controlled with monotherapy in most cases, polytherapy is used for refractory cases. A number of studies have reported the prescription patterns of antiepileptic drugs in different parts of India. Such reports are lacking in Manipur. Therefore, the present study was planned to know prescribing patterns of antiepileptic drugs in epilepsy patients in Manipur. Material and Methods: A retrospective cross-sectional analysis of prescriptions of epilepsy patients attending Therapeutic Drug Monitoring (TDM) unit in the Regional Institute of Medical Sciences, Imphal, Manipur was planned. Prescriptions of 65 epilepsy patients attending TDM unit during November, 2013 to January, 2017 were analysed with respect to demographic profiles, seizures types and number of drugs prescribed. Results were expressed in percentages. Results: Out of 65 patients, 64.61% were males. Undetermined seizures were 35.38% followed by generalised tonic clonic seizure (26.15%), complex partial seizures (21.54%), secondarily generalised (12.31%) and simple partial seizures (4.61%) respectively. Two drugs combinations were found in 38.46% followed by 1 drug treatments (35.38%), 3 drugs (16.92%) and 4 drugs combinations (9.23%) respectively. Most commonly prescribed drugs were Oxcarbazepine in monotherapy (47.83%), Oxcarbazepine with Clobazam in 2 drugs combinations (36%), Oxcarbazepine, Clobazam with Levetiracetam in 3 drugs combinations and Oxcarbazepine, Phenobarbitone, Levetiracetam and Divalproex in 4 drugs combinations (33.33%). Conclusion: Newer antiepileptic drugs were more frequently prescribed. Oxcarbazepine topped the list of prescriptions followed by Clobazam and Levetiracetam. Two drugs combination treatment was the commonest approach followed by monotherapy.
Authors and Affiliations
Ngangom Gunindro, Sania Monica Kholi, Yumnam Sarita Devi, Leishangthem J oshila, N. Hemantakumar, Krishna Pramodini Devi
A Comparative Study of Intrathecal Fentanyl and Dexmedetomidine as Adjuvants to Bupivacaine
Introduction: Spinal anaesthesia is the most preferred regional anaesthesia technique. Present study was done to study the efficacy of Intrathecal Fentanyl and Dexmedetomidine with 0.5% heavy Bupivacaine for infra umbili...
Syndromic Approach to Diagnosis of Viral Thrombocytopenic Fever
Introduction: Acute febrile illness with thrombocytopenia is quite common in the tropics. Most of them have a benign course with nonspecific symptoms. Dengue polymerase chain reaction (PCR) and viral cultures are expensi...
Evaluation of the Effects of 0.03% Tacrolimus on Schirmer Tear Test and Tear Film Break-Up Time in Patients of Chronic Dry Eye Disease
Introduction: The aim of this study was to evaluate the effects of 0.03% tacrolimus on Schirmer tear test and tearfilm breakup time in patients with chronic dry eye disease. Material and Methods: This was a single centre...
A Clinical Study of Collagen Dressing in Partial Thickness Burns
Introduction: Burn injuries are very painful conditions which usually heal slowly and that too with scarring. They are common entities encountered in our daily clinical practice. Dressings play a vital role in the manage...
A Comparative Study of Angiogenesis and Lymphangiogenesis as Prognostic Indicators in Epithelial Ovarian Carcinoma
Introduction: Ovarian cancer is the sixth most common cancer and the seventh leading cause of cancer death among women worldwide with 90% of them being of epithelial origin. Its early detection is difficult due to the la...