Abstract

Introduction It was noticed that Fundic Gland Polyps (FGP) are more frequently seen. There are reports suggesting that this condition is associated with the use of Proton Pump Inhibition (PPI). Aim Study the incidence of FGP's and relates this with the use of PPI. Patients and methods All consecutive patients who underwent endoscopy in the years 2006-2015 in whom FGP's were seen were included. An extensive search was done in order to assess use of PPI's. As a control group all consecutive patients in 2012, in whom no macroscopic abnormalities were seen, were used. In addition, all consecutive endoscopies in almost 25 years, 1992-2015 were searched for the presence of FGP's. In addition, data on the use of PPI's in the Netherlands was collected. Results In 270 consecutive patients FGP's were diagnosed. During upper gastrointestinal endoscopy a hiatal hernia was seen in 152 patients (56.3%), reflux oesophagitis in 35 (12.9%), and metaplastic epithelium in the distal oesophagus in 22 (8.2%). Patients with FGP's were significantly more often on PPI therapy compared with controls group, p < 0.0001. The incidence of the condition shows a clear increase in 25 years. The use of PPI's also showed a clear rise. Conclusion Incidence of FGP's is rising and probably related to the increasing use of PPI's.

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