Prevalence and Association of Hyperuricemia in Patients of Newly Diagnosed Essential Hypertension
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Essential hypertension (80-95%) is more common than secondary hypertension (5-20%). The prevalence of essential hypertension increases with age. Serum uric acid is thought to play a pathogenic role in development of hypertension. The present study was done to determine the prevalence and association of hyperuricemia with newly diagnosed essential hypertension. Material and methods: 50 newly diagnosed hypertensive subjects whose BP >140/90 mmHg and aged >40 years were included as case and 50 age and sex matched normotensive subjects as control to study the prevalence and association of hyperuricemia with hypertension. All those patients were excluded from the study with known hypertension, diabetes mellitus, renal impairment, malignancy, on chemotherapy, gout, history of drug intake causes hyperuricemia/hypouricemia, less than 40 years of age, cerebro vascular accident and myocardial infarction. In all the subjects detailed history was taken and thorough physical examination and appropriate laboratory investigations were done. Serum uric acid levels were measured in all the subjects. Results: Mean serum uric acid was 5.80 ± 2.16 mg/dl in cases and 4.52 ± 1.27 mg/dl in controls (‘p’ value <0.05). A total of 13 (26%) subjects among cases and 3 (6%) subjects in control groups were hyperuricemic (Odds ratio 5.50; p <0.05). So the number of hyperuricemic patients and mean serum uric acid level were significantly higher in hypertensive cases, as compared to those of healthy normotensive controls. Conclusion: Prevalence of hyperuricemia in patients with essential hypertension was significantly higher than normal population. Hyperuricemia is significantly associated with newly diagnosed essential hypertensives.
Authors and Affiliations
Anurag Mishra, Poonam Gupta, Arvind Gupta, Sujit Kumar Verma, Ajeet Kumar Chaurasia, Dharamveer Sharma
Keywords
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