PREVALENCE AND GENOTYPE DIVERSITY OF ANAL HPV INFECTION AMONG HIV-INFECTED WOMEN IN BELEM, PARA, NORTH OF BRAZIL
Journal Title: International Journal of Microbiology Research - Year 2018, Vol 10, Issue 1
Abstract
The objective of this cross-sectional study was to determine the prevalence of anal HPV infection, genotype diversity and its relationship with demographic aspects of HIV-infected assisted in Belém, Pará, Brazil. A questionnaire regarding socio-demographic variables and sexual behavior was used and anal samples were collected from 108 women recruited from a HIV Counselling and Testing in the Belém, Pará, an important metropolis of the northern region of Brazil. A blood sample was also obtained to determine CD4+ T lymphocytes counts and viral load levels of HIV. HPV DNA was detected by PCR amplification of a conserved region of the HPV L1 gene and further genotyped with direct DNA sequencing. HPV infection was detected in 29 (26,8%). Twelve different types were found (HPV-16, 58, 59, 6, 11, 53, 61, 62, 66, 70, 71, 102) and low risk types were present in 72.4% of samples. HPV infection was positively correlated with CD4+ T lymphocytes counts. In conclusion, we found a low prevalence of HPV infection and low risk types in this cohort and we emphasize the relevance of implementation of screening program for anal cancer and HPV infection in the HIV-infected women population.
Authors and Affiliations
L. F. A. MACHADO
Keywords
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- EP ID EP361270
- DOI 10.9735/0975-5276.10.1.993-996
- Views 80
- Downloads 0
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