PREVALENCE AND SUSCEPTIBILITY OF EXTENDED SPECTRUM BETA-LACTAMASES IN URINARY ISOLATES OF ESCHERICHIA COLI IN A TERTIARY CARE HOSPITAL, CHENNAI-SOUTH INDIA
Journal Title: Internet Journal of Medical Update - Year 2011, Vol 6, Issue 1
Abstract
Extended spectrum beta – lactamases (ESBLs) are on the rise in hospital settings across the globe. The presence of ESBLs significantly affects the outcome of an infection and poses a challenge to the management of infection worldwide. Therefore, the aim of the present study is to determine the prevalence and susceptibility of extended spectrum beta – lactamase in urinary isolates of Escherichia coli (E.coli) in a tertiary care hospital, Chennai-South India. A total of 450 urinary isolates of E.coli were collected over a period of six months from April 2008 to September 2008. Antimicrobial susceptibility testing was determined to commonly used antibiotics using the modified Kirby-Bauer’s disc diffusion method. ESBL detection was done by the screening method of double disc synergy test and then confirmed by the phenotypic confirmatory test with combination disc as recommended by the Clinical Laboratory Standards Institute (CLSI) and the minimum inhibitory concentration (MIC) method using the E test strips (AB Biodisk,Sweden )- as per manufacturer’s instructions. The prevalence of E.coli ESBL was 60%. The ESBL producing isolates were significantly resistant (p < 0.01) to ampicillin, trimethoprim / sulfamethoxazole, norfloxacin and nalidixic acid as compared to non-ESBL producers. Multidrug resistance was significantly (p < 0.01) higher (69%) in ESBL positive isolates than non-ESBL isolates (21%). Knowledge of the prevalence of ESBL and resistance pattern of bacterial isolates in a geographical area will help the clinicians to formulate the guidelines for antibiotic therapy to avoid inappropriate use of extended spectrum cephalosporins.
Authors and Affiliations
Anbumani Narayanaswamy, M Mallika
Keywords
Related Articles
- EP ID EP91783
- DOI -
- Views 87
- Downloads 0
BIOMARKER RESEARCH: THE WAY FORWARD TO MODERN MEDICINE
Fundamentals of Operative Surgery, 2nd edition, by Vipul Yagnik, Publisher: Wolters Kluwer, Year 2019, 435 pages; Format: PDF and EPUB, Hardcover; ISBN 9789387506817
No
EARLY DIAGNOSIS OF CARPEL TUNNEL SYNDROME (CTS) IN INDIAN PATIENTS BY NERVE CONDUCTION STUDIES
The present study was carried out for early confirmation of clinically diagnosed patients of Carpal Tunnel Syndrome (CTS) by electro-diagnostic tests which included motor conduction, sensory conduction studies and F-wave...
EVOLUTION OF SURGICAL INTERVENTIONS FOR HYDROCEPHALUS: PATIENT PREFERENCES AND THE NEED FOR PROPER INFORMATION
The treatment of hydrocephalus has undergone remarkable transformation since it was first documented over two thousand years ago. Currently, the focus of hydrocephalus research is on minimally invasive techniques of trea...
Resistance patterns of Pseudomonas aeruginosa isolated from HIV and Non-HIV patients with lower respiratory tract infections
The increase in occurrence of infections due to opportunistic gram-negative bacilli in patients with impaired host defences emphasizes the need for information on the antibiotic susceptibility of the organisms that infec...