Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 7
Abstract
Introduction: Recognition of Acanthosis nigricans (AN) provides important opportunities for screening of obesity syndrome, dyslipidemia, hypertension and insulin resistance with diabetes mellitus 2. Considering the high prevalence of obesity among Iranian children, we designed this study to estimate the prevalence of AN and related laboratory factors in Iranian obese children. Materials and Methods: Seventy-one obese children were enrolled in this study. Diagnosis of AN was done by clinical examination. Body mass index (BMI), fasting blood sugar, total cholesterol, triglycerides (TG), alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, high- and low-density lipoprotein cholesterol, insulin, thyroidstimulating hormone, free thyroxin (fT4), calcium, phosphorus and 25-hydroxyvitamin D were measured with routine techniques. Collected data were compared between cases with AN and without AN. Independent t-test was used for comparison of variables. Results: Twenty-five of children were female (35.2%). Fortyeight children (67.6%) had AN. In 20 cases (28.2%), homeostasis model assessment-insulin resistance (HOMA-IR) was <2.5 and in 51 (71.8%), HOMA-IR was more than 2.5. Mean BMI, insulin, HOMA-IR, TG and AST levels were significantly higher in cases with AN. Conclusion: Obese children with AN are at risk of developing diabetes. Hence early identification of this feature and precise evaluation of children is recommended.
Authors and Affiliations
FATEMEH SAYARIFARD, AZADEH SAYARIFARD, BAHAR ALLAHVERDI, SARA IPAKCHI, MASTANEH MOGHTADERI, BAHAREH YAGHMAEI
Keywords
Related Articles
- EP ID EP355767
- DOI 10.7860/JCDR/2017/24902.10203
- Views 48
- Downloads 0
Dengue Vaccines: Current Status and Future Prospects
Editorial
Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment
Introduction: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide with multi functional activity in various systemic diseases. Previous studies indicate the detection of ET-1 in gingival tissues and gingival crevicu...
Prevalence of Iron Deficiency Anaemia and its Associated Factors among Reproductive Age Women in a Rural Area of Karaikal, Puducherry, India
ABSTRACT Introduction: Iron Deficiency Anaemia (IDA) is considered as one of the most common public health problem which affects low, middle and high level countries. It also affects all age groups including reproductive...
Head Rotation Manoeuvre during Flexible Bronchoscopy
Letter to Editor
The Effect of Hydro-Alcoholic Extraction of Valerian on Number and Morphology of Raphe Magnus Nucleus in Astrocytes in Rat Model
ABSTRACT Introduction: The valerian root extract has been used to treat sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocyte cells are involved in neural support, nutrition and protectio...